Ruoping Chen

TL;DR: The cloning of a cDNA coding for a CRF receptor from a human corticotropic tumor library is reported, which encodes a 415-amino acid protein comprising seven putative membrane-spanning domains and is structurally related to the calcitonin/vasoactive intestinal peptide/growth hormone-releasing hormone subfamily of G protein-coupled receptors.

TL;DR: Results suggest that CRFR1 plays an important role both in the development of a functional HPA axis and in mediating behavioral changes associated with anxiety.

TL;DR: The central distribution of CRF receptor mRNA expression is similar to, though more expansive than, that of regions reported to bind CRF, and it shows limited overlap with loci expressing CRF-binding protein.

TL;DR: Comparison of the amino acid sequences of CRF-RB and the previously cloned receptor reveals major differences in the N-terminal domain and in the extracellular loops, whereas the sequences of the intracellular loops are nearly identical.

TL;DR: In this paper, G-protein-coupled receptor proteins (CRF-R) are characterized by having sufficient binding affinity for corticotropin releasing factor such that concentrations of 10 nM of CRF occupy 50% of the binding sites of said receptor protein.