Cynthia J. Donaldson

TL;DR: This work characterized another mammalian member of the CRF family and localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region, and deduced a peptide that is related to u Rotensin and CRF, which is named urocortin, which could be an endogenous ligand for type-2 CRF receptors.

TL;DR: Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors.

TL;DR: The central distribution of CRF receptor mRNA expression is similar to, though more expansive than, that of regions reported to bind CRF, and it shows limited overlap with loci expressing CRF-binding protein.

TL;DR: Comparison of the amino acid sequences of CRF-RB and the previously cloned receptor reveals major differences in the N-terminal domain and in the extracellular loops, whereas the sequences of the intracellular loops are nearly identical.

TL;DR: The results suggest that the brain expresses a CRF receptor similar to that in the pituitary, and the structure of the cDNA for a rat brainCRF receptor (rCRF-R) which was cloned by hybridization from a ratbrain cDNA library is reported.