R
Ruth Chen Dy
Researcher at University of North Carolina at Chapel Hill
Publications - 11
Citations - 665
Ruth Chen Dy is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Tyrosine phosphorylation & Phosphorylation. The author has an hindex of 8, co-authored 11 publications receiving 660 citations.
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Journal ArticleDOI
Activation of a Novel Calcium-dependent Protein-tyrosine Kinase CORRELATION WITH c-Jun N-TERMINAL KINASE BUT NOT MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION
Hong Yu,Xiong Li,Gail S. Marchetto,Ruth Chen Dy,Deborah Hunter,Benjamin F. Calvo,Thomas L. Dawson,Matthias Wilm,Robert J. Anderegg,Lee M. Graves,H. Shelton Earp +10 more
TL;DR: In summary, cells expressing CADTK/PYK2 appear to have two alternative JNK activation pathways: one stress-activated and the other calcium-dependent.
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Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase
TL;DR: CADTK and FAK, which both bind to some, but not necessarily the same, cytoskeletal elements, may be involved in coordinate regulation of cytoskeleton-associated tyrosine kinase structure and signaling.
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Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.
W R Huckle,Ruth Chen Dy,H S Earp +2 more
TL;DR: A link between two widely occurring signaling pathways, the tyrosine kinases and the Ca2+ second-messenger system, is demonstrated and the possible involvement of Ca(2+)-activated tyrosin kinases in the endocrine actions of AngII and [Arg8]vasopressin is suggested.
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Angiotensin II activates at least two tyrosine kinases in rat liver epithelial cells. Separation of the major calcium-regulated tyrosine kinase from p125FAK.
TL;DR: Ang II activates at least two separate tyrosine kinases in rat liver epithelial cells; p125 and a presumably novel, cytosolic 115-120-kDa protein referred to as the calcium-dependent tyrosinesine kinase.
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The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation
Shu Mang Feng,Carolyn I. Sartor,Debra Hunter,Hong Zhou,Xihui Yang,Laura S. Caskey,Ruth Chen Dy,Rebecca S. Muraoka-Cook,H. Shelton Earp +8 more
TL;DR: It is demonstrated that pharmacological inhibition of either gamma-secretase activity or HER4 tyrosine kinase activity blocked heregulin-dependent growth inhibition of SUM44 breast cancer cells, and s80HER4 signaling is sufficient for HER4- dependent growth inhibition.