Ruth I Connor

TL;DR: In this article, the authors studied the human B cell response to SARS-CoV-2 infection in mild and severe COVID-19 patients over a period of five months.

TL;DR: The association of dysregulated glucose metabolism and severe COVID‐19 suggests that SARS‐CoV‐2 pathogenesis involves a novel interplay with glucose metabolism, which is critical for understanding disease pathogenesis and developing therapies.

TL;DR: In this article, the authors report systemic and mucosal antibody responses in convalescent individuals who experienced varying severity of disease, finding that robust neutralization and phagocytosis were apparent in nasal wash samples, while mucosal neutralization was associated with nasal SARS-CoV-2-specific IgA.

TL;DR: The association of dysregulated glucose metabolism and severe Covid-19 suggests a previously unrecognized manifestation of primary SARS-CoV-2 infection, which is critical for understanding disease pathogenesis and developing therapies.

TL;DR: In this paper, a survey of the diversity of antibody-mediated antiviral functions associated with convalescent plasma was used to define plasma samples with broad activity profiles, and these polyfunctional plasma samples could be reliably identified in multiple cohorts by multiplex assay, presenting a widely deployable screening test for plasma selection and investigation of vaccine-elicited responses.