Savannah E. Butler

TL;DR: In this article, the authors report systemic and mucosal antibody responses in convalescent individuals who experienced varying severity of disease, finding that robust neutralization and phagocytosis were apparent in nasal wash samples, while mucosal neutralization was associated with nasal SARS-CoV-2-specific IgA.

TL;DR: In this article, the authors assessed antibody functionality and reactivities to peptides across the CoV2 and the 4 endemic human coronavirus (HCoV) genomes in 126 CCP donations.

TL;DR: In this paper, a survey of the diversity of antibody-mediated antiviral functions associated with convalescent plasma was used to define plasma samples with broad activity profiles, and these polyfunctional plasma samples could be reliably identified in multiple cohorts by multiplex assay, presenting a widely deployable screening test for plasma selection and investigation of vaccine-elicited responses.

TL;DR: This study functionally and phenotypically profiled plasma from eligible convalescent donors and suggested that high-throughput profiling could be used to screen donors and plasma may provide benefits beyond neutralization.

TL;DR: Analysis of coronavirus antibody fine specificities may be useful for selecting therapeutic plasma with desired functionalities for COVID-19 convalescent plasma donations.