J
James C. Geoghegan
Researcher at Dartmouth College
Publications - 53
Citations - 3789
James C. Geoghegan is an academic researcher from Dartmouth College. The author has contributed to research in topics: Sclerostin & Antibody. The author has an hindex of 26, co-authored 45 publications receiving 3175 citations. Previous affiliations of James C. Geoghegan include University of Rochester & MedImmune.
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Journal ArticleDOI
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.
David G. Winkler,May Kung Sutherland,James C. Geoghegan,Changpu Yu,Trenton Hayes,John Skonier,Diana Shpektor,Mechtild Jonas,Brian Kovacevich,Karen Staehling-Hampton,Mark Appleby,Mary E. Brunkow,John A. Latham +12 more
TL;DR: Strong expression in osteocytes suggested that sclerostin expressed by these central regulatory cells mediates bone homeostasis, and modulation of this osteocyte‐derived negative signal is therapeutically relevant for disorders associated with bone loss.
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Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.
May Kung Sutherland,James C. Geoghegan,Changpu Yu,Eileen Turcott,John Skonier,David G. Winkler,John A. Latham +6 more
TL;DR: Findings show that sclerostin selectively controls the apoptosis of bone cells, providing a novel level of control in the regulation of bone formation.
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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
C. Garrett Rappazzo,Longping V. Tse,Chengzi I. Kaku,Daniel Wrapp,Mrunal Sakharkar,Deli Huang,Laura M. Deveau,Thomas J. Yockachonis,Andrew S. Herbert,Michael B. Battles,Cecilia M. O’Brien,Michael E. Brown,James C. Geoghegan,Jonathan P. Belk,Linghang Peng,Linlin Yang,Yixuan J. Hou,Trevor Scobey,Dennis R. Burton,David Nemazee,John M. Dye,James E. Voss,Bronwyn M. Gunn,Jason S. McLellan,Ralph S. Baric,Lisa E. Gralinski,Laura M. Walker +26 more
TL;DR: In this article, the authors employed a directed evolution approach to engineer three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies for enhanced neutralization breadth and potency.
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Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids
Nathan R. Deleault,Justin R. Piro,Daniel J. Walsh,Fei Wang,Jiyan Ma,James C. Geoghegan,Surachai Supattapone +6 more
TL;DR: It is shown by purification and reconstitution that the molecule responsible for the nuclease-resistant cofactor activity in brain is endogenous phosphatidylethanolamine (PE), suggesting that unlike RNA, PE is a promiscuous cofactor for PrPSc formation in vitro.
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Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions
Nathan R. Deleault,James C. Geoghegan,Koren Nishina,Richard J. Kascsak,R. Anthony Williamson,Surachai Supattapone +5 more
TL;DR: One possible set of minimal components for efficient conversion ofPrP molecules in vitro may be surprisingly simple, consisting of PrP27–30, PrPC, and a stimulatory polyanionic compound.