L
Leonille Schweizer
Researcher at Humboldt University of Berlin
Publications - 44
Citations - 2715
Leonille Schweizer is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 28 publications receiving 2054 citations. Previous affiliations of Leonille Schweizer include German Cancer Research Center & Heidelberg University.
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Journal ArticleDOI
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Kristian W. Pajtler,Kristian W. Pajtler,Hendrik Witt,Martin Sill,David T.W. Jones,Volker Hovestadt,Fabian Kratochwil,Khalida Wani,Ruth G. Tatevossian,Chandanamali Punchihewa,Pascal Johann,Jüri Reimand,Hans-Jörg Warnatz,Marina Ryzhova,Steve Mack,Vijay Ramaswamy,David Capper,David Capper,Leonille Schweizer,Leonille Schweizer,Laura Sieber,Andrea Wittmann,Zhiqin Huang,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Daniel W. Fults,Helen Toledano,Smadar Avigad,Lindsey M. Hoffman,Andrew M. Donson,Nicholas K. Foreman,Ekkehard Hewer,Karel Zitterbart,Mark R. Gilbert,Terri S. Armstrong,Terri S. Armstrong,Nalin Gupta,Jeffrey C. Allen,Matthias A. Karajannis,David Zagzag,Martin Hasselblatt,Andreas E. Kulozik,Olaf Witt,V. Peter Collins,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Gary D. Bader,Marie-Laure Yaspo,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Michael D. Taylor,Richard J. Gilbertson,David W. Ellison,Kenneth Aldape,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Stefan M. Pfister +61 more
TL;DR: The molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Journal ArticleDOI
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.
David E. Reuss,Felix Sahm,Felix Sahm,Daniel Schrimpf,Daniel Schrimpf,Benedikt Wiestler,Benedikt Wiestler,David Capper,David Capper,Christian Koelsche,Christian Koelsche,Leonille Schweizer,Leonille Schweizer,Andrey Korshunov,Andrey Korshunov,David T.W. Jones,Volker Hovestadt,Michel Mittelbronn,Michel Mittelbronn,Jens Schittenhelm,Christel Herold-Mende,Andreas Unterberg,Michael Platten,Michael Platten,Michael Weller,Wolfgang Wick,Wolfgang Wick,Stefan M. Pfister,Stefan M. Pfister,Andreas von Deimling,Andreas von Deimling +30 more
TL;DR: An algorithm based on stepwise analysis with initial immunohistochemistry for ATRX and IDH1-R132H followed by 1p/19q analysis followed by IDH sequencing which reduces the number of molecular analyses and which has a far better association with patient outcome than WHO 2007 is presented.
Journal ArticleDOI
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein
Leonille Schweizer,Leonille Schweizer,Christian Koelsche,Christian Koelsche,Felix Sahm,Felix Sahm,Rosario M. Piro,David Capper,David Capper,David E. Reuss,David E. Reuss,Stefan Pusch,Antje Habel,Jochen Meyer,Tanja Göck,David T.W. Jones,Christian Mawrin,Jens Schittenhelm,Albert J. Becker,Stephanie Heim,Matthias Simon,Christel Herold-Mende,Gunhild Mechtersheimer,Werner Paulus,Rainer König,Rainer König,Otmar D. Wiestler,Stefan M. Pfister,Stefan M. Pfister,Andreas von Deimling,Andreas von Deimling +30 more
TL;DR: Exome sequencing was performed and the NAB2-STAT6 fusion protein was detected in DNA of 8/10 meningeal HPC thereby providing evidence of close relationship of these tumors with peripheral SFT and it is demonstrated that this fusion can be rapidly detected by STAT6 immunohistochemistry which shows a consistent nuclear reallocation.
Journal ArticleDOI
Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.
David E. Reuss,Rosario M. Piro,Rosario M. Piro,David T.W. Jones,Matthias Simon,Ralf Ketter,Marcel Kool,Albert J. Becker,Felix Sahm,Stefan Pusch,Jochen Meyer,Christian Hagenlocher,Leonille Schweizer,David Capper,Phillipp Kickingereder,Jana Mucha,Christian Koelsche,Natalie Jäger,Thomas Santarius,Patrick S. Tarpey,Philip J. Stephens,P. Andrew Futreal,Ruth Wellenreuther,Jürgen Kraus,Doris Lenartz,Christel Herold-Mende,Christian Hartmann,Christian Mawrin,Nathalia A. Giese,Roland Eils,Roland Eils,V. Peter Collins,Rainer König,Rainer König,Otmar D. Wiestler,Stefan M. Pfister,Stefan M. Pfister,Andreas von Deimling +37 more
TL;DR: An essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma is suggested and a role for TRAf7 alterations in other non-NF2 meningingiomas is demonstrated.
Journal ArticleDOI
Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma
Benedikt Wiestler,David Capper,David Capper,Martin Sill,David T.W. Jones,Volker Hovestadt,Dominik Sturm,Christian Koelsche,Christian Koelsche,Anna Marta Maria Bertoni,Leonille Schweizer,Leonille Schweizer,Andrey Korshunov,Andrey Korshunov,Elisa K. Weiß,Elisa K. Weiß,Maximilian G. Schliesser,Alexander Radbruch,Christel Herold-Mende,Patrick Roth,Andreas Unterberg,Christian Hartmann,Christian Hartmann,Christian Hartmann,Torsten Pietsch,Guido Reifenberger,Peter Lichter,Bernhard Radlwimmer,Michael Platten,Michael Platten,Stefan M. Pfister,Stefan M. Pfister,Andreas von Deimling,Andreas von Deimling,Michael Weller,Wolfgang Wick,Wolfgang Wick +36 more
TL;DR: It is suggested that anaplastic gliomas can be grouped by IDH and 1p/19q status into three molecular groups that show clear links to underlying biology and a significant association with clinical outcome in a prospective trial cohort.