R
Ryan D. Murphey
Researcher at Howard Hughes Medical Institute
Publications - 11
Citations - 2046
Ryan D. Murphey is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Zebrafish & Gene knockdown. The author has an hindex of 9, co-authored 11 publications receiving 1897 citations. Previous affiliations of Ryan D. Murphey include Boston Children's Hospital & Harvard University.
Papers
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Journal ArticleDOI
BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma
E. Elizabeth Patton,Hans R. Widlund,Jeffery L. Kutok,Kamden R. Kopani,Kamden R. Kopani,James F. Amatruda,James F. Amatruda,Ryan D. Murphey,Ryan D. Murphey,Stephane Berghmans,Elizabeth A. Mayhall,Elizabeth A. Mayhall,David Traver,David Traver,Christopher D.M. Fletcher,Jon C. Aster,Scott R. Granter,A. Thomas Look,Charles Lee,David E. Fisher,Leonard I. Zon,Leonard I. Zon +21 more
TL;DR: Direct evidence is provided that BRAF activation is sufficient for f-nevus formation, that BRAf activation is among the primary events in melanoma development, and that the p53 and BRAF pathways interact genetically to produce melanoma.
Journal ArticleDOI
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
Stephane Berghmans,Ryan D. Murphey,Erno Wienholds,Donna Neuberg,Jeffery L. Kutok,Christopher D.M. Fletcher,John P. Morris,Ting Xi Liu,Stefan Schulte-Merker,John P. Kanki,Ronald H.A. Plasterk,Leonard I. Zon,A. Thomas Look +12 more
TL;DR: These mutant zebrafish lines provide a unique platform for modifier screens to identify genetic mutations or small molecules that affect tp53-related pathways, including apoptosis, cell-cycle delay, and tumor suppression.
Book ChapterDOI
The zebrafish as a model organism to study development of the immune system.
David Traver,Philippe Herbomel,E. Elizabeth Patton,Ryan D. Murphey,Jeffrey A. Yoder,Gary W. Litman,Andre Catic,Chris T. Amemiya,Leonard I. Zon,Nikolaus S. Trede +9 more
TL;DR: Establishing the zebrafish as a model system for the study of the immune system will provide an alternative and complementary tool to the use of forward genetic screens in mice.
Journal ArticleDOI
Small molecules that delay S phase suppress a zebrafish bmyb mutant.
Howard M. Stern,Ryan D. Murphey,Jennifer L. Shepard,James F. Amatruda,Christian T. Straub,Kathleen L. Pfaff,Gerhard J. Weber,John A. Tallarico,Randall W. King,Leonard I. Zon +9 more
TL;DR: This study demonstrates that chemical suppressor screening in zebrafish can identify compounds with cell-cycle activity and can be used to identify pathways that interact with specific cell- cycle phenotypes.
Journal ArticleDOI
A chemical genetic screen for cell cycle inhibitors in zebrafish embryos.
TL;DR: It is demonstrated that small molecule screens in zebrafish can identify compounds with novel activity and thus may be useful tools for chemical genetics and drug discovery.