D
David Traver
Researcher at University of California, San Diego
Publications - 142
Citations - 18941
David Traver is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Zebrafish & Haematopoiesis. The author has an hindex of 58, co-authored 137 publications receiving 17099 citations. Previous affiliations of David Traver include Brigham and Women's Hospital & Stanford University.
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Journal ArticleDOI
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
TL;DR: The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
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CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Siddhartha Jaiswal,Catriona Jamieson,Wendy W. Pang,Christopher Y. Park,Mark P. Chao,Ravindra Majeti,David Traver,Nico van Rooijen,Irving L. Weissman +8 more
TL;DR: It is concluded that CD47 upregulation is an important mechanism that provides protection to normal HSCs during inflammation-mediated mobilization, and that leukemic progenitors co-opt this ability in order to evade macrophage killing.
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Haematopoietic stem cells derive directly from aortic endothelium during development
Julien Y. Bertrand,Neil C. Chi,Neil C. Chi,Buyung Santoso,Shutian Teng,Didier Y.R. Stainier,David Traver +6 more
TL;DR: The unique strengths of the zebrafish embryo are used to image directly the generation of HSCs from the ventral wall of the dorsal aorta and it is demonstrated that the H SCs generated from haemogenic endothelium are the lineal founders of the adult haematopoietic system.
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Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
TL;DR: The zebrafish is firmly established as a genetic model for the study of vertebrate blood development and its blood-forming system is characterized to provide a cellular context in which to study the genetics of hematopoiesis.
Journal ArticleDOI
BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma
E. Elizabeth Patton,Hans R. Widlund,Jeffery L. Kutok,Kamden R. Kopani,Kamden R. Kopani,James F. Amatruda,James F. Amatruda,Ryan D. Murphey,Ryan D. Murphey,Stephane Berghmans,Elizabeth A. Mayhall,Elizabeth A. Mayhall,David Traver,David Traver,Christopher D.M. Fletcher,Jon C. Aster,Scott R. Granter,A. Thomas Look,Charles Lee,David E. Fisher,Leonard I. Zon,Leonard I. Zon +21 more
TL;DR: Direct evidence is provided that BRAF activation is sufficient for f-nevus formation, that BRAf activation is among the primary events in melanoma development, and that the p53 and BRAF pathways interact genetically to produce melanoma.