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Shuang Liu
Researcher at Central South University
Publications - 247
Citations - 11995
Shuang Liu is an academic researcher from Central South University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 49, co-authored 217 publications receiving 9359 citations. Previous affiliations of Shuang Liu include DuPont & Purdue University.
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Journal ArticleDOI
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
Michael J. Gandal,Pan Zhang,Evi Hadjimichael,Rebecca L. Walker,Chao Chen,Shuang Liu,Hyejung Won,Harm van Bakel,Merina Varghese,Yongjun Wang,Annie W. Shieh,Jillian R. Haney,Sepideh Parhami,Judson Belmont,Minsoo Kim,Patricia Moran Losada,Zenab Khan,Justyna Mleczko,Yan Xia,Yan Xia,Rujia Dai,Rujia Dai,Daifeng Wang,Yucheng T. Yang,Min Xu,Kenneth N. Fish,Patrick R. Hof,Jonathan Warrell,Dominic Fitzgerald,Kevin P. White,Andrew E. Jaffe,Mette A. Peters,Mark Gerstein,Chunyu Liu,Chunyu Liu,Chunyu Liu,Lilia M. Iakoucheva,Dalila Pinto,Daniel H. Geschwind +38 more
TL;DR: This work integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder, schizophrenia, and bipolar disorder, as well as controls to identify causal drivers and define a mechanistic basis for the composite activity of genetic risk variants.
Journal ArticleDOI
Comprehensive functional genomic resource and integrative model for the human brain
Daifeng Wang,Daifeng Wang,Shuang Liu,Jonathan Warrell,Hyejung Won,Xu Shi,Fabio C. P. Navarro,Declan Clarke,Mengting Gu,Prashant Emani,Yucheng T. Yang,Min Xu,Michael J. Gandal,Shaoke Lou,Jing Zhang,Jonathan J. Park,Chengfei Yan,Suhn K. Rhie,Kasidet Manakongtreecheep,Holly Zhou,Aparna Nathan,Mette A. Peters,Eugenio Mattei,Dominic Fitzgerald,Tonya M. Brunetti,Jill Moore,Yan Jiang,Kiran Girdhar,Gabriel E. Hoffman,Selim Kalayci,Zeynep H. Gümüş,Gregory E. Crawford,Panos Roussos,Schahram Akbarian,Andrew E. Jaffe,Kevin P. White,Zhiping Weng,Nenad Sestan,Daniel H. Geschwind,James A. Knowles,Mark Gerstein +40 more
TL;DR: The resource and integrative analyses have uncovered genomic elements and networks in the brain, which in turn have provided insight into the molecular mechanisms underlying psychiatric disorders.
Journal ArticleDOI
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
Mingfeng Li,Gabriel Santpere,Yuka Imamura Kawasawa,Yuka Imamura Kawasawa,Oleg V. Evgrafov,Forrest O. Gulden,Sirisha Pochareddy,Susan M. Sunkin,Zhen Li,Yurae Shin,Yurae Shin,Ying Zhu,André M. M. Sousa,Donna M. Werling,Robert R. Kitchen,Hyo Jung Kang,Hyo Jung Kang,Mihovil Pletikos,Mihovil Pletikos,Jinmyung Choi,Sydney Muchnik,Xuming Xu,Daifeng Wang,Belen Lorente-Galdos,Shuang Liu,Paola Giusti-Rodríguez,Hyejung Won,Christiaan de Leeuw,Antonio F. Pardiñas,PsychENCODE Developmental Subgroup,Ming Hu,Fulai Jin,Yun Li,Michael John Owen,Michael Conlon O'Donovan,James T.R. Walters,Danielle Posthuma,Mark Reimers,Pat Levitt,Pat Levitt,Daniel R. Weinberger,Thomas M. Hyde,Joel E. Kleinman,Daniel H. Geschwind,Michael Hawrylycz,Matthew W. State,Stephen Sanders,Patrick F. Sullivan,Mark Gerstein,Ed S. Lein,James A. Knowles,Nenad Sestan +51 more
TL;DR: The generation and analysis of a variety of genomic data modalities at the tissue and single-cell levels, including transcriptome, DNA methylation, and histone modifications across multiple brain regions ranging in age from embryonic development through adulthood, reveal insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
Journal ArticleDOI
Bifunctional chelators for therapeutic lanthanide radiopharmaceuticals.
Shuang Liu,D. S. Edwards +1 more
Journal ArticleDOI
The PsychENCODE project
Schahram Akbarian,Chunyu Liu,James A. Knowles,Flora M. Vaccarino,Peggy J. Farnham,Gregory E. Crawford,Andrew E. Jaffe,Dalila Pinto,Stella Dracheva,Daniel H. Geschwind,Jonathan Mill,Jonathan Mill,Angus C. Nairn,Alexej Abyzov,Sirisha Pochareddy,Shyam Prabhakar,Sherman M. Weissman,Patrick F. Sullivan,Matthew W. State,Zhiping Weng,Mette A. Peters,Kevin P. White,Mark Gerstein,Anahita Amiri,Chris Armoskus,Allison E. Ashley-Koch,Taejeong Bae,Andrea Beckel-Mitchener,Benjamin P. Berman,Gerhard A. Coetzee,Gianfilippo Coppola,Nancy Francoeur,Menachem Fromer,Robert Gao,Kay Grennan,Jennifer Herstein,David H. Kavanagh,Nikolay A. Ivanov,Yan Jiang,Robert R. Kitchen,Alexey Kozlenkov,Marija Kundakovic,Mingfeng Li,Zhen Li,Shuang Liu,Lara M. Mangravite,Eugenio Mattei,Eirene Markenscoff-Papadimitriou,Fabio C. P. Navarro,Nicole North,Larsson Omberg,David M. Panchision,Neelroop N. Parikshak,Jeremie Poschmann,Amanda J. Price,Michael J. Purcaro,Timothy E. Reddy,Panos Roussos,Shannon Schreiner,Soraya Scuderi,Robert Sebra,Mikihito Shibata,Annie W. Shieh,Mario Skarica,Wenjie Sun,Vivek Swarup,Amber Thomas,Junko Tsuji,Harm van Bakel,Daifeng Wang,Yongjun Wang,Kai Wang,Donna M. Werling,A. Jeremy Willsey,Heather Witt,Hyejung Won,Chloe C. Y. Wong,Chloe C. Y. Wong,Gregory A. Wray,Emily Wu,Xuming Xu,Lijing Yao,Geetha Senthil,Thomas Lehner,Pamela Sklar,Nenad Sestan +85 more
TL;DR: The PsychENCODE project aims to produce a public resource of multidimensional genomic data using tissue- and cell type–specific samples from approximately 1,000 phenotypically well-characterized, high-quality healthy and disease-affected human post-mortem brains, as well as functionally characterize disease-associated regulatory elements and variants in model systems.