Ryan Garrity

TL;DR: It is shown that pharmacological elevation of circulating succinate drives UCP1-dependent thermogenesis by brown adipose tissue in vivo, which stimulates robust protection against diet-induced obesity and improves glucose tolerance, and reveals an unexpected mechanism for control of thermogenesis.

TL;DR: In this article, a single infusion of lipid nanoparticles was shown to reduce levels of PCSK9 and low-density lipoprotein cholesterol in the liver of a cynomolgus macaque.

TL;DR: Oximouse is developed, a comprehensive and quantitative mapping of the mouse cysteine redox proteome in vivo that comprehensively identifies redox-modified disease networks that remodel in aged mice, establishing a systemic molecular basis for the long-standing proposed links between redox dysregulation and tissue aging.

TL;DR: This work records AAC currents directly from inner mitochondrial membranes from various mouse tissues and identifies two distinct transport modes: ADP/ATP exchange and H+ transport, which suggests that the H+ leak and mitochondrial uncoupling could be dynamically controlled by cellular ATP demand and the rate ofADP/ ATP exchange.

TL;DR: A bioenergetic sensor in muscle is defined that utilizes intracellular pH and succinate to coordinate tissue adaptation to exercise.