R
Ryan J. H. West
Researcher at University of York
Publications - 25
Citations - 412
Ryan J. H. West is an academic researcher from University of York. The author has contributed to research in topics: Synapse & Neurodegeneration. The author has an hindex of 10, co-authored 22 publications receiving 288 citations. Previous affiliations of Ryan J. H. West include University of Manchester & University of Sheffield.
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Journal ArticleDOI
Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia.
TL;DR: Rab8, POSH, and TAK1 regulate synaptic growth responses, which suggests that recycling endosomes are key compartments for synaptic growth regulation in neurodegenerative processes.
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Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila.
Matthew C. W. Oswald,Paul S Brooks,Maarten Zwart,Amrita Mukherjee,Ryan J. H. West,Carlo N.G. Giachello,Khomgrit Morarach,Richard A. Baines,Sean T. Sweeney,Matthias Landgraf +9 more
TL;DR: This study identified the highly conserved Parkinson’s disease-linked protein DJ-1β as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway.
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Neurophysiology of Drosophila Models of Parkinson’s Disease
TL;DR: An insight is provided into the role Drosophila has played in elucidating neurophysiological perturbations associated with Parkinson's disease- (PD-) related genes and the genetic tractability of Drosophile offers the chance to separate fundamental changes from downstream consequences.
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Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle.
Anja Katzemich,Ryan J. H. West,Atsushi Fukuzawa,Sean T. Sweeney,Mathias Gautel,John C. Sparrow,Belinda Bullard +6 more
TL;DR: It is shown that Ball and MASK act downstream of obscurin, and both are needed for development of a well defined M-line and Z-disc, suggesting that the kinase domains act as a scaffold binding Ball andMASK.
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Oxidative stress and autophagy: mediators of synapse growth?
Ryan J. H. West,Sean T. Sweeney +1 more
TL;DR: The observations that oxidative stress responses, potentially acting through autophagy, can generate synaptic growth suggest that ROS may be a potent regulator of synapse size and function.