M
Merrilee Needham
Researcher at Fiona Stanley Hospital
Publications - 113
Citations - 3102
Merrilee Needham is an academic researcher from Fiona Stanley Hospital. The author has contributed to research in topics: Medicine & Inclusion body myositis. The author has an hindex of 26, co-authored 90 publications receiving 2389 citations. Previous affiliations of Merrilee Needham include University of Notre Dame & University of Notre Dame Australia.
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Journal ArticleDOI
Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches
TL;DR: This review covers the clinical presentation, diagnosis, treatment, and the latest information on genetic susceptibility and pathogenesis of sporadic inclusion body myositis.
Journal ArticleDOI
Progressive myopathy with up-regulation of MHC-I associated with statin therapy.
Merrilee Needham,Victoria A. Fabian,Wally Knezevic,Peter K. Panegyres,P.J. Zilko,Frank L. Mastaglia +5 more
TL;DR: Observations suggest that statins may initiate an immune-mediated myopathy that persists after withdrawal of the drug and responds to immunosuppressive therapy.
Journal ArticleDOI
Evaluation and construction of diagnostic criteria for inclusion body myositis
Thomas E. Lloyd,Andrew L. Mammen,Anthony A. Amato,Michael D. Weiss,Merrilee Needham,Steven A. Greenberg +5 more
TL;DR: This study provides Class II evidence that published expert consensus–derived IBM diagnostic categories accurately distinguish IBM from other muscle disease with high specificity but wide-ranging sensitivities.
Journal ArticleDOI
Use of Whole-Exome Sequencing for Diagnosis of Limb-Girdle Muscular Dystrophy: Outcomes and Lessons Learned
Roula Ghaoui,Sandra T. Cooper,Sandra T. Cooper,Monkol Lek,Kristi J. Jones,Kristi J. Jones,Alastair Corbett,Stephen W. Reddel,Merrilee Needham,Christina Liang,Leigh B. Waddell,Leigh B. Waddell,Garth A. Nicholson,Gina L. O'Grady,Gina L. O'Grady,Simranpreet Kaur,Simranpreet Kaur,Royston Ong,Mark R. Davis,Carolyn M. Sue,Nigel G. Laing,Kathryn N. North,Daniel G. MacArthur,Nigel F. Clarke,Nigel F. Clarke +24 more
TL;DR: The central goals were to improve the genetic diagnosis of LGMD, investigate whether the WES platform provides adequate coverage of known LGMD-related genes, and identify new LGMD -related genes.
Journal ArticleDOI
Persistence on therapy and propensity matched outcome comparison of two subcutaneous interferon beta 1a dosages for multiple sclerosis.
Tomas Kalincik,Tim Spelman,Maria Trojano,Pierre Duquette,Guillermo Izquierdo,Pierre Grammond,Alessandra Lugaresi,Raymond Hupperts,Edgardo Cristiano,Vincent Van Pesch,Francois Grand'Maison,Daniele Spitaleri,Maria Edite Rio,S. Flechter,Celia Oreja-Guevara,Giorgio Giuliani,Aldo Savino,Maria Pia Amato,Thor Petersen,Ricardo Fernandez-Bolanos,Roberto Bergamaschi,Gerardo Iuliano,Cavit Boz,Jeannette Lechner-Scott,Norma Deri,Orla Gray,Freek Verheul,Marcela Fiol,Michael Barnett,Erik van Munster,Vetere Santiago,Fraser Moore,Mark Slee,Maria Laura Saladino,Raed Alroughani,Cameron Shaw,Krisztian Kasa,Tatjana Petkovska-Boskova,Leontien Den Braber-Moerland,Joab Chapman,Eli Skromne,Joseph Herbert,Dieter Poehlau,Merrilee Needham,Elizabeth A. Bacile,Walter Oleschko Arruda,Mark Paine,Bhim Singhal,Steve Vucic,Jose Antonio Cabrera-Gomez,Helmut Butzkueven,Helmut Butzkueven +51 more
TL;DR: Propensity score matching effectively minimised baseline covariate imbalance between two directly compared sub-populations from a large observational registry and replicating in a registry dataset derived from “real-world” database the results of the pivotal randomised trial.