R
Ryan T. Doctolero
Researcher at University of California, San Diego
Publications - 8
Citations - 837
Ryan T. Doctolero is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microsatellite instability & Colorectal cancer. The author has an hindex of 8, co-authored 8 publications receiving 788 citations. Previous affiliations of Ryan T. Doctolero include Veterans Health Administration.
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Journal ArticleDOI
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer.
John M. Carethers,E. Julieta Smith,Cynthia Behling,Lanchinh Nguyen,Akihiro Tajima,Ryan T. Doctolero,Betty L. Cabrera,Ajay Goel,Christian A. Arnold,Katsumi Miyai,C. Richard Boland,C. Richard Boland +11 more
TL;DR: There is improved survival in patients with non-microsatellite instability-high tumors after 5-fluorouracil-based chemotherapy that does not extend to patients with microsatellite Stability, consistent with in vitro studies.
Journal ArticleDOI
Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.
Barbara H. Jung,Ryan T. Doctolero,Akihiro Tajima,Alexie K. Nguyen,Temitope O. Keku,Robert S. Sandler,John M. Carethers +6 more
TL;DR: ACVR2 mutations are highly frequent in MSI-H colon cancers and in most cases cause loss of ACVR2 expression, indicating biallelic inactivation of the gene.
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Diet, Lifestyle, and Genomic Instability in the North Carolina Colon Cancer Study
Jessie A. Satia,Temitope O. Keku,Joseph A. Galanko,Christopher Martin,Ryan T. Doctolero,Akihiro Tajima,Robert S. Sandler,John M. Carethers,John M. Carethers +8 more
TL;DR: Refined carbohydrate and red meat consumption may promote development of MSI-H tumors, whereas β-carotene may be associated with lower risk.
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Influence of Race on Microsatellite Instability and CD8 + T Cell Infiltration in Colon Cancer
John M. Carethers,John M. Carethers,Bhavya Murali,Bing Yang,Ryan T. Doctolero,Akihiro Tajima,Ranor C. B. Basa,E. Julieta Smith,Monte Lee,Ryan Janke,Tina Ngo,Ruth Tejada,Ming Ji,Matthew A. Kinseth,Betty L. Cabrera,Katsumi Miyai,Temitope O. Keku,Christopher F. Martin,Joseph A. Galanko,Robert S. Sandler,Kathleen L. McGuire +20 more
TL;DR: Africans with colorectal cancer show half the MSI prevalence of Caucasians without change in CD8+ T cell infiltration which may contribute towards their higher mortality from colon cancer.
Journal ArticleDOI
Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers.
Barbara H. Jung,Barbara H. Jung,E. Julieta Smith,Ryan T. Doctolero,Pascal Gervaz,Julio C. Alonso,Katsumi Miyai,Temitope O. Keku,Robert S. Sandler,John M. Carethers,John M. Carethers +10 more
TL;DR: Mutations in TGFBR2 and BAX may improve survival in MSI‐H Dukes B2 patients, and mutations of ACVR2 may augment histological changes consistent with poor tumor grade that is characteristic of MSI‐h colon cancers, and increase tumor size.