J
John M. Carethers
Researcher at University of Michigan
Publications - 227
Citations - 11407
John M. Carethers is an academic researcher from University of Michigan. The author has contributed to research in topics: Microsatellite instability & Colorectal cancer. The author has an hindex of 52, co-authored 199 publications receiving 9723 citations. Previous affiliations of John M. Carethers include University of Texas Medical Branch & University of California, Berkeley.
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Journal ArticleDOI
Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis
TL;DR: In this paper, the authors identify microsatellite instability and chromosome instability in colorectal cancer cells and determine the effects of the different forms of genomic instability on the biological and clinical behavior of colon tumors.
REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis
TL;DR: Determining the causes and roles of genomic and epigenomic instability in colon tumor formation has the potential to yield more effective prevention strategies and therapeutics for patients with colorectal cancer.
Journal Article
Human Chromosome 3 Corrects Mismatch Repair Deficiency and Microsatellite Instability and Reduces N-Methyl-N′-nitro-N-nitrosoguanidine Tolerance in Colon Tumor Cells with Homozygous hMLH1 Mutation
Minoru Koi,Asad Umar,Dharminder Chauhan,S. P. Cherian,John M. Carethers,Thomas A. Kunkel,C. R. Boland +6 more
TL;DR: The hypothesis that mutations in both alleles of the hMLH1 gene are necessary for the manifestation of defective mismatch repair and microsatellite instability and for enhanced MNNG tolerance is supported.
Journal ArticleDOI
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer.
John M. Carethers,E. Julieta Smith,Cynthia Behling,Lanchinh Nguyen,Akihiro Tajima,Ryan T. Doctolero,Betty L. Cabrera,Ajay Goel,Christian A. Arnold,Katsumi Miyai,C. Richard Boland,C. Richard Boland +11 more
TL;DR: There is improved survival in patients with non-microsatellite instability-high tumors after 5-fluorouracil-based chemotherapy that does not extend to patients with microsatellite Stability, consistent with in vitro studies.
Journal ArticleDOI
Mismatch repair proficiency and in vitro response to 5-fluorouracil
John M. Carethers,Dharam P. Chauhan,D Fink,Sibylle Nebel,Robert S. Bresalier,Stephen B. Howell,C. Richard Boland +6 more
TL;DR: Intact DNA MMR seems to recognize 5-FU incorporated into DNA but may do so in a different manner than other types of alkylation damage, suggesting defective DNA MMR might be one mechanism for tumor resistance to5-FU.