R
Ryo Ogawa
Researcher at Tohoku University
Publications - 16
Citations - 680
Ryo Ogawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Myelin oligodendrocyte glycoprotein & Optic neuritis. The author has an hindex of 8, co-authored 13 publications receiving 422 citations.
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Journal ArticleDOI
MOG antibody–positive, benign, unilateral, cerebral cortical encephalitis with epilepsy
Ryo Ogawa,Ichiro Nakashima,Toshiyuki Takahashi,Kimihiko Kaneko,Tetsuya Akaishi,Yoshiki Takai,Douglas Kazutoshi Sato,Shuhei Nishiyama,Tatsuro Misu,Hiroshi Kuroda,Masashi Aoki,Kazuo Fujihara +11 more
TL;DR: The features of adult patients with benign, unilateral cerebral cortical encephalitis positive for the myelin oligodendrocyte glycoprotein (MOG) antibody mean the pathology may be autoimmune, although the findings differ from MOG antibody–associated demyelination and Rasmussen and other known immune-mediated encephalitides.
Journal ArticleDOI
CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications.
Kimihiko Kaneko,Douglas Kazutoshi Sato,Ichiro Nakashima,Ichiro Nakashima,Ryo Ogawa,Tetsuya Akaishi,Yoshiki Takai,Shuhei Nishiyama,Toshiyuki Takahashi,Tatsuro Misu,Hiroshi Kuroda,Satoru Tanaka,Kyoichi Nomura,Yuji Hashimoto,Dagoberto Callegaro,Lawrence Steinman,Kazuo Fujihara,Masashi Aoki +17 more
TL;DR: The CSF cytokine profile in the acute phase of MOG-IgG+ disease is characterised by coordinated upregulation of T helper 17 (Th17) and other cytokines including some Th1-related and regulatory T cells-related ones in adults and children, which is similar to AQP4-IGG+ NMOSD but clearly different from MS.
Journal ArticleDOI
The pathological features of MOG antibody-positive cerebral cortical encephalitis as a new spectrum associated with MOG antibodies: A case report.
Toshimasa Ikeda,Kentaro Yamada,Ryo Ogawa,Yoshiki Takai,Kimihiko Kaneko,Tatsuro Misu,Kaoru Kamimoto,Noriyuki Matsukawa,Mari Yoshida +8 more
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Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody.
Kazuhiro Kurosawa,Tatsuro Misu,Yoshiki Takai,Douglas Kazutoshi Sato,Douglas Kazutoshi Sato,Douglas Kazutoshi Sato,Toshiyuki Takahashi,Yoichiro Abe,Hiroko Iwanari,Ryo Ogawa,Ichiro Nakashima,Kazuo Fujihara,Takao Hamakubo,Masato Yasui,Masashi Aoki +14 more
TL;DR: The data suggest that the pathogenic antibodies could induce immune mediated astrocytopathy with mobilized neutrophils, resulted in early lesion expansion of NMO lesion with vacuolation and other tissue damages.
Journal ArticleDOI
Difference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder
Tetsuya Akaishi,Toshiyuki Takahashi,Tatsuro Misu,Kimihiko Kaneko,Yoshiki Takai,Shuhei Nishiyama,Ryo Ogawa,Juichi Fujimori,Tadashi Ishii,Masashi Aoki,Kazuo Fujihara,Ichiro Nakashima +11 more
TL;DR: In this paper, the differences in the source and the level of intrathecal synthesis between anti-aquaporin-4 antibodies (AQP4-IgG) and anti-myelin oligodendrocyte glycoprotein antibodies (MOG-G) were studied for the antibody titers in the sera and CSF simultaneously collected in the acute attacks.