R
Ryuichiro Atarashi
Researcher at University of Miyazaki
Publications - 68
Citations - 9028
Ryuichiro Atarashi is an academic researcher from University of Miyazaki. The author has contributed to research in topics: PrPSc Proteins & Scrapie. The author has an hindex of 28, co-authored 64 publications receiving 8141 citations. Previous affiliations of Ryuichiro Atarashi include Nagasaki University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Type I interferon protects neurons from prions in in vivo models.
Daisuke Ishibashi,Takujiro Homma,Takehiro Nakagaki,Takayuki Fuse,Kazunori Sano,Katsuya Satoh,Tsuyoshi Mori,Ryuichiro Atarashi,Noriyuki Nishida +8 more
TL;DR: Using cell culture and animal models of prion diseases, Ishibashi et al. show that type I interferon signalling interferes with prion infection in mammals, and a selective type I Interferon receptor agonist inhibits prion invasion and prolongs survival of prionsinfected mice, suggesting potential clinical applications.
Journal ArticleDOI
Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits.
Takeshi Fuchigami,Yuki Yamashita,Masao Kawasaki,Ayaka Ogawa,Mamoru Haratake,Mamoru Haratake,Ryuichiro Atarashi,Kazunori Sano,Takehiro Nakagaki,Kaori Ubagai,Masahiro Ono,Sakura Yoshida,Noriyuki Nishida,Morio Nakayama +13 more
TL;DR: SPECT/computed tomography imaging and ex vivo autoradiography demonstrated that [123I]SC-OMe showed consistent brain distribution with the presence of PrPSc deposits in the mBSE-infected mice brain, appearing a promising SPECT radioligand for monitoring prion deposit levels in the living brain.
Journal ArticleDOI
A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion.
Tsuyoshi Mori,Ryuichiro Atarashi,Ryuichiro Atarashi,Kana Furukawa,Hanae Takatsuki,Katsuya Satoh,Kazunori Sano,Takehiro Nakagaki,Daisuke Ishibashi,Kazuko Ichimiya,Masahisa Hamada,Takehisa Nakayama,Noriyuki Nishida +12 more
TL;DR: A newly developed in vitro amplification system, designated real-time quaking-induced conversion (RT-QuIC), has allowed the activity of abnormal prion proteins to be assessed within a few days, and showed high sensitivity for prions.
Journal ArticleDOI
Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients
Hanae Takatsuki,Takayuki Fuse,Takehiro Nakagaki,Tsuyoshi Mori,Ban Mihara,Masaki Takao,Masaki Takao,Yasushi Iwasaki,Mari Yoshida,Shigeo Murayama,Ryuichiro Atarashi,Noriyuki Nishida,Katsuya Satoh +12 more
TL;DR: Results showed thatPrion-seeding activities reach 106/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion- seeding activity exists inNon-neural organs, and it was suggested that non-NEural tissues of106/g SD50 did not exist the infectivity.
Journal ArticleDOI
Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases.
Nozomi Aibara,Kunihiro Ichinose,Miyako Baba,Hideki Nakajima,Katsuya Satoh,Ryuichiro Atarashi,Naoya Kishikawa,Noriyuki Nishida,Atsushi Kawakami,Naotaka Kuroda,Kaname Ohyama +10 more
TL;DR: This report is the first to comprehensively identify the antigens incorporated into ICs in CSF, and may be a new and promising path to biomarker discovery for diagnosis and study for CNS autoimmune diseases.