R
Ryuichiro Atarashi
Researcher at University of Miyazaki
Publications - 68
Citations - 9028
Ryuichiro Atarashi is an academic researcher from University of Miyazaki. The author has contributed to research in topics: PrPSc Proteins & Scrapie. The author has an hindex of 28, co-authored 64 publications receiving 8141 citations. Previous affiliations of Ryuichiro Atarashi include Nagasaki University & National Institutes of Health.
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Journal ArticleDOI
Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106.
Keiji Uchiyama,Hironori Miyata,Yoshitaka Yamaguchi,Morikazu Imamura,Mariya Okazaki,Agriani Dini Pasiana,Junji Chida,Hideyuki Hara,Ryuichiro Atarashi,Hitomi Watanabe,Gen Kondoh,Suehiro Sakaguchi +11 more
TL;DR: Results suggest that residues 91–106 or 91–104 of PrPC are crucially involved in prion pathogenesis in a strain-dependent manner and may play a similar role to digitonin and heparin in the conversion of Pr PC into PrPSc.
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Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain
Takeshi Fuchigami,Masao Kawasaki,Ryusuke Koyama,Mari Nakaie,Takehiro Nakagaki,Kazunori Sano,Ryuichiro Atarashi,Sakura Yoshida,Mamoru Haratake,Masahiro Ono,Noriyuki Nishida,Morio Nakayama +11 more
TL;DR: The development of 125I-labeled iodobenzofuran (IBF) derivatives as single photon emission computed tomography (SPECT) imaging probes to detect cerebralPrPSc deposits showed prospective binding properties to PrPSc.
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Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system.
Morikazu Imamura,Naoko Tabeta,Yoshifumi Iwamaru,Hanae Takatsuki,Tsuyoshi Mori,Ryuichiro Atarashi +5 more
TL;DR: This paper used recombinant prion protein from a baculovirus-insect cell expression system (Bac-rPrP) and insect cell-derived cofactors to determine whether Bac-r-PrPSc is spontaneously produced in intermittent ultrasonic reactions.
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Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain.
Takeshi Fuchigami,Masao Kawasaki,Hiroyuki Watanabe,Takehiro Nakagaki,Kodai Nishi,Kazunori Sano,Ryuichiro Atarashi,Mari Nakaie,Sakura Yoshida,Masahiro Ono,Noriyuki Nishida,Morio Nakayama +11 more
TL;DR: SPECT/computed tomography imaging and ex vivo autoradiography demonstrated that the [123I]IPBF-NHMe distribution in brain tissues of mBSE-infected mice co-localized with PrPSc deposits, appearing to be a prospective SPECT tracer for monitoring prion deposits in living brain tissues.
The Absence of Prion-Like Infectivity in Mice expressing Prion Protein-Like Protein
TL;DR: It is indicated that PrPLP/Dpl have no potential to undergo pathogenic conversion to form a prion-like infectious particle.