S
S. Engelborghs
Researcher at University of Antwerp
Publications - 48
Citations - 4370
S. Engelborghs is an academic researcher from University of Antwerp. The author has contributed to research in topics: Dementia & Stroke. The author has an hindex of 28, co-authored 48 publications receiving 4009 citations.
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Journal ArticleDOI
Genome-wide association study indentifies variants at CLU and CR1 associated with Alzheimer’s disease
J-C Lambert,Simon Heath,G Even,Dominique Campion,K. Sleegers,Mikko Hiltunen,O Cambarros,Diana Zelenika,María J. Bullido,Béatrice Tavernier,Luc Letenneur,Karolien Bettens,Claudine Berr,Florence Pasquier,Nathalie Fievet,P Barbager-Gateau,S. Engelborghs,P.P. De Deyn,Ignacio Mateo,A Franck,Seppo Helisalmi,Elisa Porcellini,Olivier Hanon,M de Pancorbo,Corinne Lendon,Carole Dufouil,C Jaillard,Thierry Léveillard,Alvarez,Paolo Bosco,Michelangelo Mancuso,Francesco Panza,Benedetta Nacmias,Paola Bossù,Paola Piccardi,Giorgio Annoni,Davide Seripa,Daniela Galimberti,Didier Hannequin,Federico Licastro,Hilkka Soininen,Karen Ritchie,Hélène Blanché,J. F. Dartigues,Christophe Tzourio,Ivo Gut,Christine Van Broeckhoven,Annick Alpérovitch,P. Amouyel +48 more
Journal ArticleDOI
Genetic contribution of FUS to frontotemporal lobar degeneration
T Van Langenhove,J. van der Zee,K. Sleegers,S. Engelborghs,Rik Vandenberghe,I. Gijselinck,M Van den Broeck,Maria Mattheijssens,K. Peeters,P.P. De Deyn,Marc Cruts,C. Van Broeckhoven +11 more
TL;DR: In a first analysis of FUS in patients with frontotemporal lobar degeneration (FTLD), a novel FUS missense mutation, M254V, is identified in 1 patient with pure FTLD, suggesting that G-insertions/deletions within this G-rich region may be tolerated.
Journal ArticleDOI
A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques.
Bart Dermaut,Samir Kumar-Singh,S. Engelborghs,Jessie Theuns,Rosa Rademakers,Jos Saerens,Barbara A. Pickut,Karin Peeters,Marleen Van den Broeck,Krist'l Vennekens,Stephen Claes,Marc Cruts,Patrick Cras,Jean Jacques Martin,Christine Van Broeckhoven,Peter Paul De Deyn +15 more
TL;DR: A novel PS1 mutation is reported in a patient with Pick‐type tauopathy in the absence of extracellular β‐amyloid deposits and is predicted to substitute Gly→Val at codon position 183 (Gly183Val) and to affect the splice signal at the junction of the sixth exon and intron.
Journal ArticleDOI
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.
Nathalie Brouwers,C. Van Cauwenberghe,S. Engelborghs,J-C Lambert,J-C Lambert,J-C Lambert,Karolien Bettens,N Le Bastard,Florence Pasquier,A Gil Montoya,K. Peeters,Maria Mattheijssens,Rik Vandenberghe,P.P. De Deyn,Marc Cruts,P. Amouyel,Kristel Sleegers,C. Van Broeckhoven +17 more
TL;DR: The data showed that the common AD risk association may well be explained by the presence of CR1-S increasing the number of C3b/C4b and cofactor activity sites and AD risk with 30% in CR2-S carriers, and how precisely the different functional role of CR 1-S in the immune complement cascade contributes to AD pathogenesis will need additional functional studies.
Journal ArticleDOI
Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease.
Nathalie Demeester,Graciela Castro,C Desrumaux,C De Geitere,Jean-Charles Fruchart,Patrick Santens,E. Mulleners,S. Engelborghs,P.P. De Deyn,Joël Vandekerckhove,Maryvonne Rosseneu,Christine Labeur +11 more
TL;DR: CSF lipoproteins induced a significant cholesterol efflux from cultured rat astrocytes, suggesting that they play an active role in maintaining the cholesterol homeostasis in brain cells.