P
Patrick Santens
Researcher at Ghent University Hospital
Publications - 230
Citations - 8521
Patrick Santens is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Parkinson's disease & Frontotemporal lobar degeneration. The author has an hindex of 43, co-authored 218 publications receiving 7840 citations. Previous affiliations of Patrick Santens include Ghent University.
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Journal ArticleDOI
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
Marc Cruts,Ilse Gijselinck,Julie van der Zee,Sebastiaan Engelborghs,Hans Wils,Daniel Pirici,Rosa Rademakers,Rik Vandenberghe,Bart Dermaut,Jean-Jacques Martin,Cornelia M. van Duijn,Karin Peeters,Raphael Sciot,Patrick Santens,Tim De Pooter,Maria Mattheijssens,Marleen Van den Broeck,Ivy Cuijt,Krist'l Vennekens,Peter Paul De Deyn,Samir Kumar-Singh,Christine Van Broeckhoven +21 more
TL;DR: It is demonstrated that FTDU-17 is caused by mutations in the gene coding for progranulin (PGRN), a growth factor involved in multiple physiological and pathological processes including tumorigenesis, and evidence that P GRN haploinsufficiency leads to neurodegeneration because of reduced PGRN-mediated neuronal survival is provided.
Journal ArticleDOI
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.
Ilse Gijselinck,Tim Van Langenhove,Julie van der Zee,Kristel Sleegers,Stéphanie Philtjens,Gernot Kleinberger,Jonathan Janssens,Karolien Bettens,Caroline Van Cauwenberghe,Sandra Pereson,Sebastiaan Engelborghs,Anne Sieben,Anne Sieben,Peter De Jonghe,Rik Vandenberghe,Patrick Santens,Jan De Bleecker,Githa Maes,Veerle Bäumer,Lubina Dillen,Geert Joris,Ivy Cuijt,Ellen Corsmit,Ellen Elinck,Jasper Van Dongen,Steven Vermeulen,Marleen Van den Broeck,Carolien Vaerenberg,Maria Mattheijssens,Karin Peeters,Wim Robberecht,Patrick Cras,Jean-Jacques Martin,Peter Paul De Deyn,Marc Cruts,Christine Van Broeckhoven +35 more
TL;DR: The GGGGCC repeat expansion is highly penetrant, explaining all of the contribution of chromosome 9p21 to FTLD and ALS in the Flanders-Belgian cohort and decreased expression of C9orf72 in brain suggests haploinsufficiency as an underlying disease mechanism.
Journal ArticleDOI
Multisubject learning for common spatial patterns in motor-imagery BCI
TL;DR: The details of the multitask CSP algorithm are outlined, results on two data sets are shown and a clear improvement can be seen, especially when the number of training trials is relatively low.
Journal ArticleDOI
Treatment of Parkinson's disease with pergolide and relation to restrictive valvular heart disease.
Guy Van Camp,Anja Flamez,Bernard Cosyns,Caroline Weytjens,Luc Muyldermans,Michel Van Zandijcke,Johan De Sutter,Patrick Santens,Pierre Decoodt,Christian Moerman,Danny Schoors +10 more
TL;DR: Clinicians should consider changing to a non-ergot drug if this disease is diagnosed, and pergolide treatment was stopped because of restrictive valvular heart disease, in six patients, in two of whom regression of disease was shown.
Journal ArticleDOI
A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats
Julie van der Zee,Ilse Gijselinck,Lubina Dillen,Tim Van Langenhove,Jessie Theuns,Sebastiaan Engelborghs,Stéphanie Philtjens,Mathieu Vandenbulcke,Kristel Sleegers,Anne Sieben,Anne Sieben,Veerle Bäumer,Githa Maes,Ellen Corsmit,Barbara Borroni,Alessandro Padovani,Silvana Archetti,Robert Perneczky,Janine Diehl-Schmid,Alexandre de Mendonça,Gabriel Miltenberger-Miltenyi,Sónia Pereira,José Pimentel,Benedetta Nacmias,Silvia Bagnoli,Sandro Sorbi,Caroline Graff,Caroline Graff,Huei-Hsin Chiang,Marie Westerlund,Raquel Sánchez-Valle,Albert Lladó,Ellen Gelpi,Isabel Santana,Maria Rosário Almeida,Beatriz Santiago,Giovanni B. Frisoni,Orazio Zanetti,Cristian Bonvicini,Matthis Synofzik,Walter Maetzler,Jennifer Müller vom Hagen,Ludger Schöls,Michael T. Heneka,Michael T. Heneka,Frank Jessen,Frank Jessen,Radoslav Matej,Eva Parobkova,Gabor G. Kovacs,Thomas Ströbel,Stayko Sarafov,Ivailo Tournev,Ivailo Tournev,Albena Jordanova,Adrian Danek,Thomas Arzberger,Gian Maria Fabrizi,Silvia Testi,Eric Salmon,Patrick Santens,Jean-Jacques Martin,Patrick Cras,Rik Vandenberghe,Peter Paul De Deyn,Marc Cruts,Christine Van Broeckhoven,Peter Paul De Deyn,Alfredo Ramirez,Delia Kurzwelly,Carmen Sachtleben,Wolfgang Mairer,Clara Firmo,Anna Antonell,José Luis Molinuevo,Anne Kinhult Ståhlbom,Håkan Thonberg,Inger Nennesmo,Anne Börjesson-Hanson,Valentina Bessi,Irene Piaceri,Maria Helena Ribeiro,Catarina R. Oliveira,João Massano,Carolina Garret,Paula Pires,Adrian Danel,Sergio Ferrari,Tiziana Cavallaro +88 more
TL;DR: In vitro reporter gene expression studies demonstrated significantly decreased transcriptional activity of C9orf72 with increasing number of normal repeat units, indicating that intermediate repeats might act as predisposing alleles and in favor of the loss‐of‐function disease mechanism.