S
S.M. Morley
Researcher at University of Dundee
Publications - 18
Citations - 1480
S.M. Morley is an academic researcher from University of Dundee. The author has contributed to research in topics: Keratin & Epidermolysis bullosa simplex. The author has an hindex of 16, co-authored 18 publications receiving 1411 citations.
Papers
More filters
Journal ArticleDOI
Keratin 16 and keratin 17 mutations cause pachyonychia congenita.
Whi McLean,E.L. Rugg,Declan P. Lunny,S.M. Morley,E. B. Lane,O. Swensson,Patricia J.C. Dopping-Hepenstal,W.A.D. Griffiths,Robin A.J. Eady,Caroline Higgins,Harshad Navsaria,Irene M. Leigh,Tom Strachan,L. Kunkeler,Colin S. Munro +14 more
TL;DR: It is shown that Jadassohn–Lewandowsky PC is caused by a heterozygous missense mutation in the helix initiation peptide of K16 (Leu130Pro), and the known expression patterns of these keratins in epidermal structures correlates with the specific abnormalities observed in each form of PC.
Journal ArticleDOI
A Homozygous Missense Mutation in TGM5 Abolishes Epidermal Transglutaminase 5 Activity and Causes Acral Peeling Skin Syndrome
Andrew Cassidy,Maurice A.M. van Steensel,Peter M. Steijlen,Michel van Geel,Jaap J A J van der Velden,S.M. Morley,Alessandro Terrinoni,Gerry Melino,Eleonora Candi,W.H. Irwin McLean +9 more
TL;DR: It is demonstrated that the protein cross-linking function performed by TG5 is vital for maintaining cell-cell adhesion between the outermost layers of the epidermis.
Journal ArticleDOI
Expression of individual lamins in basal cell carcinomas of the skin.
R S Venables,R S Venables,S McLean,D Luny,E Moteleb,S.M. Morley,Roy A. Quinlan,E. B. Lane,Christopher J. Hutchison,Christopher J. Hutchison +9 more
TL;DR: The hypothesis that lamin A has a negative influence on cell proliferation and its down regulation may be a requisite of tumour progression is supported.
Journal ArticleDOI
Phase IIa randomized, placebo-controlled study of antimicrobial photodynamic therapy in bacterially colonized, chronic leg ulcers and diabetic foot ulcers: a new approach to antimicrobial therapy
S.M. Morley,John Griffiths,G. Philips,Harry Moseley,C. O’Grady,K. Mellish,C.L. Lankester,B. Faris,R.J. Young,S B Brown,Lesley E. Rhodes +10 more
TL;DR: This work has shown that following light activation, cationic photosensitizer PPA904 [3,7‐bis(N,N‐dibutylamino) phenothiazin‐5‐ium bromide] kills a broad spectrum of bacteria in vitro and this has a variety of potential clinical applications.
Journal ArticleDOI
Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE).
W.H. Irwin McLean,Robin A.J. Eady,Patricia J.C. Dopping-Hepenstal,James R. McMillan,Irene M. Leigh,Harshad Navsaria,Caroline Higgins,John I. Harper,D. Paige,S.M. Morley,E. Birgitte Lane +10 more
TL;DR: Four diverse keratin mutations are described that are all significantly associated with bullous congenital ichthyosiform erythroderma and create restriction fragment length polymorphisms that were used to exclude the mutations from 120 normal chromosomes.