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Declan P. Lunny
Researcher at University of Dundee
Publications - 18
Citations - 1835
Declan P. Lunny is an academic researcher from University of Dundee. The author has contributed to research in topics: Keratin & Hair follicle. The author has an hindex of 16, co-authored 17 publications receiving 1737 citations. Previous affiliations of Declan P. Lunny include University of Utah.
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Journal ArticleDOI
The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases
Ildikó Szeverényi,Andrew Cassidy,Cheuk Wang Chung,Bernett Lee,John E.A. Common,Stephen C. Ogg,Huijia Chen,Shu Yin Sim,Walter Goh,Kee Woei Ng,John A. Simpson,Li Lian Chee,Goi Hui Eng,Bin Li,Declan P. Lunny,Danny Chuon,Aparna Venkatesh,Kian Hoe Khoo,W.H. Irwin McLean,Yun Ping Lim,E. Birgitte Lane +20 more
TL;DR: A revised and expanded database on human intermediate filament proteins, a major component of the eukaryotic cytoskeleton, it is anticipated that the HIFD will provide a useful resource to study human genome variations for basic scientists, clinicians, and students alike.
Journal ArticleDOI
Keratin 16 and keratin 17 mutations cause pachyonychia congenita.
Whi McLean,E.L. Rugg,Declan P. Lunny,S.M. Morley,E. B. Lane,O. Swensson,Patricia J.C. Dopping-Hepenstal,W.A.D. Griffiths,Robin A.J. Eady,Caroline Higgins,Harshad Navsaria,Irene M. Leigh,Tom Strachan,L. Kunkeler,Colin S. Munro +14 more
TL;DR: It is shown that Jadassohn–Lewandowsky PC is caused by a heterozygous missense mutation in the helix initiation peptide of K16 (Leu130Pro), and the known expression patterns of these keratins in epidermal structures correlates with the specific abnormalities observed in each form of PC.
Journal ArticleDOI
Lamin B1 fluctuations have differential effects on cellular proliferation and senescence
Oliver Dreesen,Alexandre Chojnowski,Peh Fern Ong,Tian Yun Zhao,John E.A. Common,Declan P. Lunny,E. Birgitte Lane,Shu Jin Lee,Leah A. Vardy,Colin L. Stewart,Alan Colman +10 more
TL;DR: Both LMNB1 depletion and overexpression inhibit proliferation, but onlyLMNB1 overexpressed induces senescence.
Journal ArticleDOI
Clinical and pathological features of pachyonychia congenita.
Sancy A. Leachman,Roger L. Kaspar,Philip Fleckman,Scott R. Florell,Frances J.D. Smith,W.H. Irwin McLean,Declan P. Lunny,Leonard M Milstone,Maurice A.M. van Steensel,Colin S. Munro,Edel A. O'Toole,Julide Tok Celebi,A. Kansky,E. Birgitte Lane +13 more
TL;DR: Analysis of clinical, pathological, and genetic data from the literature and two research registries reveal that >97% of PC cases exhibit fingernail and toenail thickening, and painful plantar keratoderma.
Journal ArticleDOI
Assessment of p53 protein expression in normal, benign, and malignant oral mucosa
TL;DR: The identification of p53 within biopsies of oral mucosal lesions would appear to correlate with oral malignancy.