S
S. Motoyoshi
Researcher at Kumamoto University
Publications - 6
Citations - 3109
S. Motoyoshi is an academic researcher from Kumamoto University. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 6, co-authored 6 publications receiving 3014 citations.
Papers
More filters
Journal ArticleDOI
Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study.
Yasuo Ohkubo,Hideki Kishikawa,Eiichi Araki,Takao Miyata,S. Isami,S. Motoyoshi,Yujiro Kojima,Naohiko Furuyoshi,Motoaki Shichiri +8 more
TL;DR: In conclusion, intensive glycemic control by multiple insulin injection therapy can delay the onset and the progression of diabetic retinopathy, nephropathy and neuropathy in Japanese patients with NIDDM.
Journal ArticleDOI
Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.
S. Isami,Hideki Kishikawa,Eiichi Araki,M. Uehara,Kengo Kaneko,Tetsuya Shirotani,Mikio Todaka,S. Ura,S. Motoyoshi,K. Matsumoto,Nobuhiro Miyamura,Motoaki Shichiri +11 more
TL;DR: It is concluded that bradykinin could potentiate insulin induced glucose uptake through GLUT4 translocation by upregulating the insulin receptor tyrosine kinase activity which stimulates phosphorylation of IRS-1, followed by GLUT 4 translocation.
Journal ArticleDOI
Molecular scanning of the insulin receptor substrate.1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms
S. Ura,Eiichi Araki,Hideki Kishikawa,Tetsuya Shirotani,Mikio Todaka,S. Isami,Seiya Shimoda,Ryohei Yoshimura,Kohji Matsuda,S. Motoyoshi,Nobuhiro Miyamura,C R Kahn,Motoaki Shichiri +12 more
TL;DR: IRS-1 polymorphisms may contribute in part to the insulin resistance and development of NIDDM in Japanese subjects; however, they do not account for the major part of the decrease in insulin-stimulated glucose uptake which is observed in subjects with clinically apparent NID DM.
Journal ArticleDOI
Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes : Insulin secretion in response to physiological concentrations of glucose
S. Motoyoshi,Tetsuya Shirotani,Eiichi Araki,K. Sakai,Kengo Kaneko,Hiroyuki Motoshima,Kazuaki Yoshizato,Atsuhisa Shirakami,Hideki Kishikawa,Motoaki Shichiri +9 more
TL;DR: The results suggest that both GLUT2 and glucokinase are necessary for the glucose stimulated insulin secretion in at least rodent cell lines, and that other element(s) are needed for a biphasic insulin secretion typically observed in beta cells.
Journal ArticleDOI
The treatment of pheochromocytoma associated with pseudo-obstruction and perforation of the colon, hepatic failure, and DIC.
Yasuyoshi Hashimoto,S. Motoyoshi,Hideki Maruyama,Michiharu Sakakida,Tomohiko Yano,Kohei Yamaguchi,Kazuo Goto,S Sugihara,Sadamu Takano,Takeshi Kambara,Motoaki Shichiri +10 more
TL;DR: The case of a 59-year-old man with paralytic ileus (pseudo-obstruction) associated with pheochromocytoma is reviewed and the significant role of catecholamines in causing these symptoms is discussed, and the management of this relatively rare complication is reviewed.