S. Sahoo

TL;DR: It is found that these TRPV inhibitors may regulate mitogenic and T cell receptor mediated T cell activation and effector cytokine(s) production by suppressing tumour necrosis factor, interleukin‐2 and interferon‐γ release.

TL;DR: The present findings suggest that expression of CHIKV proteins were maximum at 8 hpi and the release of new viral progenies were remarkably increased around 12 hpi, which suggests activation of apoptosis through both intrinsic and extrinsic pathways in Chikungunya virus infected macrophages.

TL;DR: A comparative study on an experimental and theoretical optimization of magneto-optical Kerr setups based on photoelastic modulation and phase sensitive detector methodology finds one particular setup which maximizes I(omega) as well as I2 omega and maximizes the signal-to-noise ratio.

TL;DR: It is demonstrated that TRPA1 is endogenously expressed in primary murine splenic T cells as well as in primary human T cells, and results may have implication in T cell-mediated responses and indicate possible role ofTRPA1 in immunological disorders.

TL;DR: For the first time it has been shown that CHIKV triggers robust TNF production in the host macrophages via both p-p38 and p-JNK/p-c-jun pathways and the interaction of viral protein, nsP2 with these MAPKs during infection.