Saburo Neya

TL;DR: In this article, a general and rigorous theory for equilibrium concentrations of uncomplexed species and 1 : 1, 1 : 2, 2 : 1 and 2 : 2 complexes of cyclodextrin (D) and surfactant has been developed and applied to evaluate the binding constants of these complexations from surface tension data of aqueous solutions of dodecyl maltoside (DM) with α-, β-, and γ-D, reported by Saeger and Muller-Fahrnow.

TL;DR: The difference in levels of resistance to the three inhibitors has been explained from energetic and structural viewpoints, which provides the suggestion for promising drugs keeping its efficacy even for the L90M mutant.

TL;DR: In this article, the binding constants and solution structures of α-cyclodextrin (α-CD) complexes with hexyltrimethylammonium (HTAB) and OTAB bromides were determined from the best correlations between the ROE intensities and the interproton distances.

TL;DR: A comparison in distribution of lipid molecules between the two kinds of membranes suggested that cholesterol had important roles to prevent the membrane from interdigitation and to stabilize other lipids for interacting with each other.

TL;DR: Results show that M36I regulates the size of the binding cavity of the protease, and the reason for the rare emergence of D30N variants in non-subtype B HIV-1 proteases was clarified from the computational analysis.