Sadaki Fujimoto

TL;DR: The present results suggest that, in AD, NADPH oxidase is activated in microglia, resulting in the formation of reactive oxygen species which can be toxic to neighboring neurons in AD.

TL;DR: Polymorphisms in the ATP-binding cassette (ABC) transporter genes, MDR1, MRP1 and MRP2, were associated with their respective mRNA expression levels in duodenal enterocytes of 13 healthy Japanese volunteers to support the lower serum concentrations of digoxin after single oral administration in the subjects with the mutant T-allele at position 3435.

TL;DR: Immunoblot analysis of brain extracts from embryonic day 19 to postnatal 96-week-old rats indicated that caspase-3 levels were high from E19 to 2 weeks, while caspasing-2 remained high from 4 to 96 weeks, indicating that the expression of casp enzyme-2 and -3 is differentially regulated during development and aging.

TL;DR: Immunostaining of a specific antibody against the PLC isozyme, PLC-delta, demonstrated that this enzyme was abnormally accumulated in neurofibrillary tangles, neurites surrounding senile plaque cores, and neuropil threads in AD brains.

TL;DR: The present results suggest that the expression of each Bcl-2 family protein is differentially regulated during development and aging and that the changes in the senescent brains are different from those observed in AD.