S
Sadie L. Marjani
Researcher at Central Connecticut State University
Publications - 18
Citations - 742
Sadie L. Marjani is an academic researcher from Central Connecticut State University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 10, co-authored 17 publications receiving 579 citations. Previous affiliations of Sadie L. Marjani include Yale University.
Papers
More filters
Journal ArticleDOI
Comprehensive annotation of the transcriptome of the human fungal pathogen Candida albicans using RNA-seq
Vincent M. Bruno,Zhong Wang,Sadie L. Marjani,Ghia Euskirchen,Jeffrey Martin,Gavin Sherlock,Michael Snyder +6 more
TL;DR: This comprehensive transcriptome analysis significantly enhances the current genome annotation of C. albicans, a necessary framework for a complete understanding of the molecular mechanisms of pathogenesis for this important eukaryotic pathogen.
Journal ArticleDOI
Two methods for full-length RNA sequencing for low quantities of cells and single cells
Xinghua Pan,Russell E. Durrett,Haiying Zhu,Yoshiaki Tanaka,Yumei Li,Xiaoyuan Zi,Sadie L. Marjani,Ghia Euskirchen,Chao Ma,Chao Ma,Robert H. LaMotte,In-Hyun Park,Michael Snyder,Christopher E. Mason,Sherman M. Weissman +14 more
TL;DR: These protocols for the amplification and high-throughput sequencing of very small amounts of RNA for sequencing using procedures of either semirandom primed PCR or phi29 DNA polymerase-based DNA amplification, for the cDNA generated with oligo-dT and/or random oligonucleotide primers are reported.
Journal ArticleDOI
Single-Cell Sequencing for Precise Cancer Research: Progress and Prospects
Xiao-Yan Zhang,Sadie L. Marjani,Zhaoyang Hu,Sherman M. Weissman,Xinghua Pan,Xinghua Pan,Shixiu Wu +6 more
TL;DR: The current methods for single cancer-cell sequencing are discussed, with a strong focus on those practically used or potentially valuable in cancer research, including single-cell isolation, whole genome and transcriptome amplification, epigenome profiling, multi-dimensional sequencing, and next-generation sequencing and analysis.
Journal ArticleDOI
Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment.
TL;DR: The emerging knowledge of tumor genomics and heterogeneity is reviewed, as well as potential implications for precision medicine in cancer treatment and new therapeutic discoveries.
Journal ArticleDOI
Methylome Dynamics of Bovine Gametes and in vivo Early Embryos.
Jingyue Duan,Zongliang Carl Jiang,Fahad Alqahtani,Ion I. Mandoiu,Dong Hong,Zheng Xinbao,Sadie L. Marjani,Jingbo Chen,Xiuchun Cindy Tian +8 more
TL;DR: This comprehensive analysis provides insight into the critical features of the bovine embryo methylome, and serves as an important reference for embryos produced in vitro, such as by in vitro fertilization and cloning.