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Sadie L. Marjani
Researcher at Central Connecticut State University
Publications - 18
Citations - 742
Sadie L. Marjani is an academic researcher from Central Connecticut State University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 10, co-authored 17 publications receiving 579 citations. Previous affiliations of Sadie L. Marjani include Yale University.
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Journal ArticleDOI
DNA methylomes of bovine gametes and in vivo produced preimplantation embryos.
Zongliang Jiang,Jianan Lin,Jianan Lin,Dong Hong,Zheng Xinbao,Sadie L. Marjani,Jingyue Duan,Zhengqing Ouyang,Zhengqing Ouyang,Jingbo Chen,Xiuchun Cindy Tian +10 more
TL;DR: Genome-wide gene-specific DNA methylation in bovine sperm, oocytes and preimplantation embryos is determined using reduced representation bisulfite sequencing to provide insights into the complex epigenetic reprogramming of bovines early embryos.
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mRNA Levels of Imprinted Genes in Bovine In Vivo Oocytes, Embryos and Cross Species Comparisons with Humans, Mice and Pigs.
Zongliang Jiang,Dong Hong,Zheng Xinbao,Sadie L. Marjani,David M. Donovan,Jingbo Chen,Xiuchun Cindy Tian +6 more
TL;DR: The data presented here provide a solid reference for expression profiles of imprinted genes in embryos produced using assisted reproductive biotechnologies and compared these genes to their counterparts in mice, humans and pigs.
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Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells.
Lin Han,Hua-Jun Wu,Haiying Zhu,Haiying Zhu,Kun-Yong Kim,Sadie L. Marjani,Markus Riester,Ghia Euskirchen,Xiaoyuan Zi,Xiaoyuan Zi,Jennifer Yang,Jasper Han,Michael Snyder,In-Hyun Park,Rafael A. Irizarry,Sherman M. Weissman,Franziska Michor,Rong Fan,Xinghua Pan,Xinghua Pan +19 more
TL;DR: A novel method for genome-wide CpG island (CGI) methylation sequencing for single cells (scCGI-seq), combining methylation-sensitive restriction enzyme digestion and multiple displacement amplification for selective detection of methylated CGIs is reported.
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Next-generation molecular diagnosis: single-cell sequencing from bench to bedside
Wanjun Zhu,Wanjun Zhu,Xiao-Yan Zhang,Sadie L. Marjani,Jialing Zhang,Wengeng Zhang,Shixiu Wu,Xinghua Pan,Xinghua Pan +8 more
TL;DR: This review provides an overview of the current progress and prospects for the diagnostic applications of SCS, specifically in pre-implantation genetic diagnosis/screening, non-invasive prenatal diagnosis, and analysis of circulating tumor cells.
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Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and Telomeres
Hua Wang,Peng Gong,Peng Gong,Tong Chen,Shan Gao,Zhenfeng Wu,Xiaodong Wang,Jie Li,Sadie L. Marjani,Jose Costa,Sherman M. Weissman,Feng Qi,Xinghua Pan,Xinghua Pan,Lin Liu +14 more
TL;DR: In this article, simultaneous measurement of telomere length and transcriptome in the same cells enables systematic assessment of cancer stem cells (CSCs) in primary colorectal cancer (CRC).