S
Sagun Parakh
Researcher at La Trobe University
Publications - 64
Citations - 1070
Sagun Parakh is an academic researcher from La Trobe University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 46 publications receiving 688 citations. Previous affiliations of Sagun Parakh include Monash University & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Antibody–Drug Conjugates for Cancer Therapy
TL;DR: An overview of the biology and chemistry of each component of ADC design is provided, including the role of molecular imaging in drug development, and perspectives about the future development of the next generations of ADCs are concluded.
Journal ArticleDOI
Antibody-Drug Conjugates for Cancer Therapy
TL;DR: Key issues impacting on the clinical success of ADCs in cancer therapy include better patient selection for treatment and the identification of mechanisms of therapy resistance.
Journal ArticleDOI
Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy.
Samantha Bowyer,Prashanth Prithviraj,Paul Lorigan,James Larkin,Grant A. McArthur,Victoria Atkinson,Michael Millward,Michael Millward,M. Khou,Stefan Diem,S. Ramanujam,Benjamin Y. Kong,Elizabeth Liniker,Alexander Guminski,Phillip Parente,Miles C. Andrews,Sagun Parakh,Jonathan Cebon,Georgina V. Long,Matteo S. Carlino,Matteo S. Carlino,Oliver Klein +21 more
TL;DR: Ipilimumab therapy can induce responses in patients who fail the anti-PD-1 therapy with response rates comparable to previous reports, but there appears to be an increased frequency of high-grade immune-related adverse events including pneumonitis that warrants close surveillance.
Journal ArticleDOI
Efficacy of anti-PD-1 therapy in patients with melanoma brain metastases
Sagun Parakh,John J. Park,Shehara Mendis,Rajat Rai,Wen Xu,Serigne Lo,Martin Drummond,Catherine Rowe,Annie Wong,Grant A. McArthur,Andrew Haydon,Miles C. Andrews,Jonathan Cebon,Alexander Guminski,Alexander Guminski,Richard F. Kefford,Richard F. Kefford,Georgina V. Long,Georgina V. Long,Alexander M. Menzies,Alexander M. Menzies,Oliver Klein,Matteo S. Carlino,Matteo S. Carlino +23 more
TL;DR: IC responses to anti-PD-1 antibodies occur in patients with melanoma brain metastasis, including those with symptomatic BM requiring corticosteroids, and Prospective trials evaluating anti- PD-1 therapy in pts with BM are underway.
Journal ArticleDOI
Evolution of anti-HER2 therapies for cancer treatment.
Sagun Parakh,Sagun Parakh,Hui K Gan,Hui K Gan,Adam C. Parslow,Ingrid Burvenich,Antony W. Burgess,Andrew M. Scott +7 more
TL;DR: Molecular imaging with HER2 antibodies has the potential to be a non-invasive, predictive and prognostic technique capable of influencing therapeutic decisions, predicting response and failure of treatments as well as providing insights into receptor recycling and signalling.