S
Sajal Afzal
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 7
Citations - 127
Sajal Afzal is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Cancer & Downregulation and upregulation. The author has an hindex of 5, co-authored 7 publications receiving 90 citations. Previous affiliations of Sajal Afzal include University of Tsukuba.
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Journal ArticleDOI
New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy.
Muhammad Hassan Safdar,Zahid Hussain,Mohammed A.S. Abourehab,Humna Hasan,Sajal Afzal,Hnin Ei Thu +5 more
TL;DR: This review extends detailed insight into the engineering of HA-based nanomedicines, characterization, utilization for the diagnosis or treatment of CD44 over-expressing cancer subtypes and emphasizing the transition of nanomedicsines to clinical cancer therapy.
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Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence.
Sukant Garg,Sajal Afzal,Ahmed Elwakeel,Damini Sharma,Navaneethan Radhakrishnan,Jaspreet Kaur Dhanjal,Durai Sundar,Sunil C. Kaul,Renu Wadhwa +8 more
TL;DR: Investigation of fucoxanthin activities in human cancer cell culture-based viability, migration, and molecular assays found that it possesses strong anticancer and anti-metastatic activities that work irrespective of the p53 status of cancer cells.
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Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin.
Sajal Afzal,Sajal Afzal,Sukant Garg,Yoshiyuki Ishida,Keiji Terao,Sunil C. Kaul,Renu Wadhwa,Renu Wadhwa +7 more
TL;DR: Anti-stress and differentiation-inducing potential of two marine bioactive carotenoids using rat glioma cells as a model found that the low (nontoxic) doses of both protected cells against UV-induced DNA damage, heavy metal, and heat-induced protein misfolding and aggregation of proteins.
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Bioinformatics and Molecular Insights to Anti-Metastasis Activity of Triethylene Glycol Derivatives.
Vidhi Malik,Sukant Garg,Sajal Afzal,Jaspreet Kaur Dhanjal,Chae-Ok Yun,Sunil C. Kaul,Durai Sundar,Renu Wadhwa +7 more
TL;DR: It is demonstrated that TD-10 and TD-11 target stress chaperone mortalin at the transcription and translational level, yielding decreased expression of vimentin, fibronectin and hnRNP-K, and increase in extracellular matrix (ECM) proteins endorsing reversal of epithelial–mesenchymal transition (EMT) signaling.
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Exploring Promising Immunomodulatory Potential of Natural and Synthetic 1,3-Diphenyl-2-propen-1-one Analogs: A Review of Mechanistic Insight.
TL;DR: This review critically reviewed the literature and provided convincing evidence for the promising efficacy of chalcone derivatives to modulate functioning of various innate and adaptive immune players including granulocytes, mast cells, monocytes, macrophages, platelets, dendritic cells, natural killer cells, and T-lymphocytes.