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Ahmed Elwakeel
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 7
Citations - 80
Ahmed Elwakeel is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Cancer cell & Downregulation and upregulation. The author has an hindex of 3, co-authored 4 publications receiving 32 citations. Previous affiliations of Ahmed Elwakeel include University of Tsukuba.
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Journal ArticleDOI
Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence.
Sukant Garg,Sajal Afzal,Ahmed Elwakeel,Damini Sharma,Navaneethan Radhakrishnan,Jaspreet Kaur Dhanjal,Durai Sundar,Sunil C. Kaul,Renu Wadhwa +8 more
TL;DR: Investigation of fucoxanthin activities in human cancer cell culture-based viability, migration, and molecular assays found that it possesses strong anticancer and anti-metastatic activities that work irrespective of the p53 status of cancer cells.
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Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells
Amr Omar,Amr Omar,Rajkumar Singh Kalra,Jayarani F. Putri,Ahmed Elwakeel,Ahmed Elwakeel,Sunil C. Kaul,Sunil C. Kaul,Renu Wadhwa,Renu Wadhwa +9 more
TL;DR: It is demonstrated that Snol-A is a natural inhibitor of CARF and may be recruited as a potent anti-tumor and anti-metastasis compound for treatment of p53-deficient aggressive malignancies.
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A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms
Anissa Nofita Sari,Jaspreet Kaur Dhanjal,Ahmed Elwakeel,Vipul Kumar,Hazna Noor Meidinna,Huayue Zhang,Yoshiyuki Ishida,Keiji Terao,Durai Sundar,Sunil C. Kaul,Renu Wadhwa +10 more
TL;DR: The data supported that this novel combination of Wi-A and CAPE may be recruited for the treatment of metastatic and aggressive cancers and, hence, warrant further evaluation by recruiting a variety of experimental and clinical metastatic models.
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Metabolites of Cannabis Induce Cardiac Toxicity and Morphological Alterations in Cardiac Myocytes
Ayse Orme Merve,Pola Sobiecka,Vytautas Remeškevičius,Luke Taylor,Lili Saskoy,Scott P Lawton,Ben P. Jones,Ahmed Elwakeel,Francesca E. Mackenzie,Elena Polycarpou,Jason Bennett,Brian Rooney +11 more
TL;DR: Investigations in the planarian animal model Polycelis nigra demonstrated that treatments with cannabinoid metabolites resulted in increased protein deposition at transection sites while higher doses resulted in significant lethality and decline in regeneration.
Journal ArticleDOI
Mutant p53L194F Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to MortaparibPlus, a Multimodal Small Molecule Inhibitor.
Ahmed Elwakeel,Ahmed Elwakeel,Anissa Nofita Sari,Anissa Nofita Sari,Jaspreet Kaur Dhanjal,Jaspreet Kaur Dhanjal,Hazna Noor Meidinna,Hazna Noor Meidinna,Durai Sundar,Sunil C. Kaul,Renu Wadhwa,Renu Wadhwa +11 more
TL;DR: In this article, the authors performed a drug screening to identify a potential inhibitor of mortalin-p53 interaction and found that MortaparibPlus (4]-(1E)-2-(2-phenylindol-3-yl)-1-azavinyl]-1,2,4-triazole) is capable of abrogating mortalin p53 interaction.