S
Salvatore Valitutti
Researcher at University of Toulouse
Publications - 114
Citations - 10188
Salvatore Valitutti is an academic researcher from University of Toulouse. The author has contributed to research in topics: T-cell receptor & Cytotoxic T cell. The author has an hindex of 44, co-authored 103 publications receiving 9331 citations. Previous affiliations of Salvatore Valitutti include Catholic University of the Sacred Heart & Stanford University.
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Journal ArticleDOI
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Nils Holler,Rossana Zaru,Olivier Micheau,Margot Thome,Antoine Attinger,Salvatore Valitutti,Jean-Luc Bodmer,Pascal Schneider,Brian Seed,Jürg Tschopp +9 more
TL;DR: F Fas kills activated primary T cells efficiently in the absence of active caspases, which results in necrotic morphological changes and late mitochondrial damage but no cytochrome c release.
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Serial triggering of many T-cell receptors by a few peptide–MHC complexes
TL;DR: It is shown that a small number of peptideMHC complexes can achieve a high TCR occupancy, because a single complex can serially engage and trigger up to ∼200 TCRs.
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Sustained signaling leading to t cell activation results from prolonged t cell receptor occupancy. role of t cell actin cytoskeleton
TL;DR: T cell actin cytoskeleton is identified as a major motor for sustaining signal transduction and possibly for driving TCR cross-linking and offer an explanation for how T cells equipped with low affinity TCR can be triggered by a small number of complexes on APCs.
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Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.
TL;DR: Results indicate that a single CTL can graduate different biological responses as a function of antigen concentration and that killing of the specific target does not necessarily result in full activation.
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CARMA1 is a critical lipid raft- associated regulator of TCR-induced NF-κB activation
Olivier Gaide,Benoit Favier,Daniel F. Legler,David Bonnet,Brian Brissoni,Salvatore Valitutti,Claude Bron,Jürg Tschopp,Margot Thome +8 more
TL;DR: The data show that CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation and CD28 costimulation–dependent Jnk activation and that it was constitutively associated with lipid rafts upon TCR engagement.