D
Daniel F. Legler
Researcher at University of Konstanz
Publications - 99
Citations - 8518
Daniel F. Legler is an academic researcher from University of Konstanz. The author has contributed to research in topics: Chemokine receptor & Chemokine. The author has an hindex of 37, co-authored 90 publications receiving 7738 citations. Previous affiliations of Daniel F. Legler include University of British Columbia & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
Estelle Oberlin,Ali Amara,Françoise Bachelerie,Christine Bessia,Jean-Louis Virelizier,Fernando Arenzana-Seisdedos,Olivier Schwartz,Jean-Michel Heard,Ian Clark-Lewis,Daniel F. Legler,Marcel Loetscher,Marco Baggiolini,Bernhard Moser +12 more
TL;DR: The identification of a human chemokine of the CXC type, stromal cell-derived factor 1 (SDF-1), as the natural ligand for LESTR/fusin, and the term CXCR-4 is proposed for this receptor, in keeping with the new Chemokine-receptor nomenclature.
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B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5
Daniel F. Legler,Marcel Loetscher,Regula Stuber Roos,Ian Clark-Lewis,Marco Baggiolini,Bernhard Moser +5 more
TL;DR: The present results indicate that chemotactic recruitment by locally produced BCA-1 is important for the development of B cell areas of secondary lymphoid tissues.
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Interstitial dendritic cell guidance by haptotactic chemokine gradients.
Michele Weber,Robert Hauschild,Jan Schwarz,Christine Moussion,Ingrid de Vries,Daniel F. Legler,Sanjiv A. Luther,Tobias Bollenbach,Michael Sixt +8 more
TL;DR: These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.
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Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation
Daniel F. Legler,Daniel F. Legler,Olivier Micheau,Marie-Agnès Doucey,Jürg Tschopp,Claude Bron +5 more
TL;DR: It is suggested that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways, which leads to the degradation via the proteasome pathway.
Journal ArticleDOI
CARMA1 is a critical lipid raft- associated regulator of TCR-induced NF-κB activation
Olivier Gaide,Benoit Favier,Daniel F. Legler,David Bonnet,Brian Brissoni,Salvatore Valitutti,Claude Bron,Jürg Tschopp,Margot Thome +8 more
TL;DR: The data show that CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation and CD28 costimulation–dependent Jnk activation and that it was constitutively associated with lipid rafts upon TCR engagement.