S
Sam Horrell
Researcher at University of Essex
Publications - 17
Citations - 337
Sam Horrell is an academic researcher from University of Essex. The author has contributed to research in topics: Protein crystallization & Medicine. The author has an hindex of 9, co-authored 13 publications receiving 239 citations. Previous affiliations of Sam Horrell include University of Liverpool & University of Hamburg.
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Journal ArticleDOI
Liquid application method for time-resolved analyses by serial synchrotron crystallography.
Pedram Mehrabi,Eike C. Schulz,Eike C. Schulz,Michael Agthe,Sam Horrell,Gleb Bourenkov,David von Stetten,Jan-Philipp Leimkohl,H. Schikora,Thomas R. Schneider,Arwen R. Pearson,Friedjof Tellkamp,R. J. Dwayne Miller,R. J. Dwayne Miller,R. J. Dwayne Miller +14 more
TL;DR: A rapid sample mixing approach enables time-resolved structural studies of enzymatic reactions using serial synchrotron crystallography, and demonstrates proof-of-principle binding of GlcNac to lysozyme.
Journal ArticleDOI
Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal.
Sam Horrell,Svetlana V. Antonyuk,Robert R. Eady,S. Samar Hasnain,Michael A. Hough,Richard W. Strange +5 more
TL;DR: A structural movie of X-ray-driven enzyme catalysis has thus been obtained, revealing the structural changes that occur during the catalytic reaction in unprecedented detail.
Journal ArticleDOI
Recent structural insights into the function of copper nitrite reductases
TL;DR: In this article, the authors review the insights gained from X-ray free electron laser (XFEL) and 3-domain copper nitrite reductase (CuNiR) function from three dimensional structures.
Journal ArticleDOI
A microfluidic flow-focusing device for low sample consumption serial synchrotron crystallography experiments in liquid flow.
Diana C. F. Monteiro,Mohammad Vakili,Jessica Harich,Michael Sztucki,S. Meier,Sam Horrell,Inokentijs Josts,Martin Trebbin +7 more
TL;DR: A fast and optimized manufacturing route to metal-polyimide microfluidic flow-focusing devices which allow for the collection of X-ray diffraction data in flow and allows for full datasets to be obtained quickly from crystal slurries in liquid flow.
Journal ArticleDOI
Visualization of membrane protein crystals in lipid cubic phase using X-ray imaging
Anna J. Warren,Wes Armour,Danny Axford,Mark Basham,Thomas Connolley,David R. Hall,Sam Horrell,Katherine McAuley,Vitaliy Mykhaylyk,Armin Wagner,Gwyndaf Evans +10 more
TL;DR: A comparison of X-ray diffraction and radiographic techniques for the location and characterization of protein crystals is demonstrated on membrane protein crystals mounted within lipid cubic phase material.