D
Demet Kekilli
Researcher at Paul Scherrer Institute
Publications - 24
Citations - 780
Demet Kekilli is an academic researcher from Paul Scherrer Institute. The author has contributed to research in topics: Ligand (biochemistry) & Chemistry. The author has an hindex of 10, co-authored 20 publications receiving 458 citations. Previous affiliations of Demet Kekilli include University of Essex & University of the West of England.
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Journal ArticleDOI
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser
Przemyslaw Nogly,Tobias Weinert,Daniel James,Sergio Carbajo,Dmitry Ozerov,Antonia Furrer,Dardan Gashi,Veniamin Borin,Petr Skopintsev,Kathrin Jaeger,Karol Nass,Petra Båth,Robert Bosman,Jason E. Koglin,Matthew Seaberg,Thomas J. Lane,Demet Kekilli,Steffen Brünle,Tomoyuki Tanaka,Wenting Wu,Christopher J. Milne,Thomas P. White,Anton Barty,Uwe Weierstall,Valerie Panneels,Eriko Nango,So Iwata,Mark S. Hunter,Igor Schapiro,Gebhard F. X. Schertler,Gebhard F. X. Schertler,Richard Neutze,Jörg Standfuss +32 more
TL;DR: The principal mechanism of isomerization in this prototypical retinal-binding protein has direct relevance for all other members of this important family of membrane proteins, and it provides insight into how protein environments catalyze photochemical reactions in general.
ComponentDOI
Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography.
Tobias Weinert,Petr Skopintsev,Daniel James,Florian S. N. Dworkowski,Ezequiel Panepucci,Demet Kekilli,Antonia Furrer,Steffen Brünle,S. Mous,Dmitry Ozerov,Przemyslaw Nogly,Meitian Wang,Jörg Standfuss +12 more
TL;DR: In this article, the structural changes in the light-driven proton-pump bacteriorhodopsin over 200 milliseconds in time were recorded using synchrotrons.
Journal ArticleDOI
Femtosecond-to-millisecond structural changes in a light-driven sodium pump.
Petr Skopintsev,D. Ehrenberg,Tobias Weinert,Daniel James,Rajiv K. Kar,Philip J. M. Johnson,Dmitry Ozerov,Antonia Furrer,Isabelle Martiel,Florian S. N. Dworkowski,Karol Nass,Gregor Knopp,Claudio Cirelli,Christopher Arrell,Dardan Gashi,S. Mous,M. Wranik,Thomas Gruhl,Demet Kekilli,Steffen Brünle,Xavier Deupi,Gebhard F. X. Schertler,Gebhard F. X. Schertler,Roger Benoit,Valerie Panneels,Przemyslaw Nogly,Igor Schapiro,Christopher J. Milne,Joachim Heberle,Jörg Standfuss +29 more
TL;DR: Crystallographic ‘snapshots’ taken at intervals of femtoseconds to milliseconds after activation show how a light-activated sodium pump carries sodium ions across the cell membrane and provide direct molecular insight into the dynamics of active cation transport across biological membranes.
Posted ContentDOI
Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography
Tobias Weinert,Petr Skopintsev,Daniel James,Florian S. N. Dworkowski,Ezequiel Panepucci,Demet Kekilli,Antonia Furrer,S. Brünle,S. Mous,Dmitry Ozerov,Przemyslaw Nogly,Meitian Wang,Jörg Standfuss +12 more
TL;DR: This work adapted time-resolved serial crystallography developed at X-ray lasers to visualize protein motions using synchrotrons and recorded the structural changes upon proton pumping in bacteriorhodopsin over 200 ms in time.
Journal ArticleDOI
Recent structural insights into the function of copper nitrite reductases
TL;DR: In this article, the authors review the insights gained from X-ray free electron laser (XFEL) and 3-domain copper nitrite reductase (CuNiR) function from three dimensional structures.