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Samantha Mackin
Publications - 7
Citations - 202
Samantha Mackin is an academic researcher. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 5, co-authored 7 publications receiving 202 citations.
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Journal ArticleDOI
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains
James Brett Case,Samantha Mackin,John M. Errico,Zhenlu Chong,Emily A Madden,Bradley M. Whitener,Barbara Guarino,Michael Schmid,Kim Rosenthal,Kuishu Ren,Ha V. Dang,Gyorgy Snell,Ana Jung,Lindsay Droit,Scott A. Handley,Peter Halfmann,Yoshihiro Kawaoka,James E. Crowe,Daved H. Fremont,Herbert W. Virgin,Yueh Ming Loo,Mark T. Esser,Lisa A. Purcell,Davide Corti,Michael S. Diamond +24 more
TL;DR: In this paper , the authors report on the protection of two monoclonal antibody therapies (S309 and AZD7442) against SARS-CoV-2 Omicron lineage strains (BA.1, BA.2, and BA.1.1).
Journal ArticleDOI
Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice
Baoling Ying,Suzanne M. Scheaffer,Bradley M. Whitener,Chieh Liang,Oleksandr Dmytrenko,Samantha Mackin,Kai Wu,Diana Lee,Laura E. Avena,Zhenlu Chong,James Brett Case,LingZhi Ma,Thu Dang Kim,Caralyn E Sein,Angela Woods,Daniela Montes Berrueta,Gwo-Yu Chang,Guillaume Stewart-Jones,Isabella Renzi,Yen-Ting Lai,Agata Malinowski,Andrea Carfi,Sayda Elbashir,Darin K. Edwards,Larissa B. Thackray,Michael S. Diamond +25 more
TL;DR: In this paper , the authors evaluated the effect of Moderna mRNA-1273 vaccine against Omicron lineage variants (BA.1, BA.2, and BA.1) before or after boosting.
Posted ContentDOI
Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice
Baoling Ying,Suzanne M. Scheaffer,Bradley M. Whitener,Chieh Liang,Oleksandr Dmytrenko,Samantha Mackin,Kai Wu,Diana Lee,Laura E. Avena,Zhenlu Chong,James Brett Case,LingZhi Ma,Thu Dang Kim,Caralyn E Sein,Angela Woods,Daniela Montes Berrueta,Andrea Carfi,Sayda Elbashir,Darin K. Edwards,Larissa B. Thackray,Michael S. Diamond +20 more
TL;DR: In mice, boosting with mRNA- 1273 or mRNA-1273 enhances protection against B.1.1-CoV-2 infection with limited differences in efficacy measured, and the levels of inhibitory antibodies were higher, and viral burden and cytokines in the lung were slightly lower in mice given the Omicron-matched mRNA booster.
Journal ArticleDOI
Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2
Samantha Mackin,Pritesh Desai,Bradley M. Whitener,Courtney E. Karl,Meizi Liu,Ralph S. Baric,Darin K. Edwards,Taras M. Chicz,Ryan P. McNamara,Galit Alter,Michael S. Diamond +10 more
TL;DR: In this paper , passive and active immunization studies in mice suggest that Fc-FcγR engagement and alveolar macrophages are required for vaccine-induced antibody-mediated protection against infection by antigenically changed SARS-CoV-2 variants, including Omicron strains.
Posted ContentDOI
Fcγ receptor-dependent antibody effector functions are required for vaccine protection against infection by antigenic variants of SARS-CoV-2
Samantha Mackin,Pritesh Desai,Bradley M. Whitener,Courtney E. Karl,Meizi Liu,Ralph S. Baric,Darin K. Edwards,Taras M. Chicz,Ryan P. McNamara,Galit Alter,Michael S. Diamond +10 more
TL;DR: In this paper , passive and active immunization approaches in wild-type and Fc-gamma receptor (FcγR) KO mice were used to determine the requirement for Fc effector functions to protect against SARS-CoV-2 infection.