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Yueh Ming Loo
Researcher at University of Washington
Publications - 49
Citations - 10922
Yueh Ming Loo is an academic researcher from University of Washington. The author has contributed to research in topics: Innate immune system & Virus. The author has an hindex of 27, co-authored 42 publications receiving 9611 citations. Previous affiliations of Yueh Ming Loo include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
Mitsutoshi Yoneyama,Mika Kikuchi,Kanae Matsumoto,Tadaatsu Imaizumi,Makoto Miyagishi,Makoto Miyagishi,Kazunari Taira,Kazunari Taira,Eileen Foy,Yueh Ming Loo,Michael Gale,Shizuo Akira,Shin Yonehara,Atsushi Kato,Takashi Fujita +14 more
TL;DR: The results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors.
Journal ArticleDOI
Immune Signaling by RIG-I-like Receptors
Yueh Ming Loo,Michael Gale +1 more
TL;DR: Understanding the processes of RLR signaling and response will provide insights to guide RLR-targeted therapeutics for antiviral and immune-modifying applications.
Journal ArticleDOI
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
Yueh Ming Loo,Jamie L. Fornek,Nanette Crochet,Gagan Bajwa,Olivia Perwitasari,Luis Martinez-Sobrido,Shizuo Akira,Michelle A. Gill,Adolfo García-Sastre,Michael G. Katze,Michael Gale +10 more
TL;DR: Differential and redundant roles for RIG-I and MDA5 in pathogen recognition and innate immune signaling that may reflect unique and shared biologic properties of RNA viruses whose differential triggering and control of gene expression may impact pathogenesis and infection are demonstrated.
Journal ArticleDOI
Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I
Rhea Sumpter,Yueh Ming Loo,Eileen Foy,Kui Li,Mitsutoshi Yoneyama,Takashi Fujita,Stanley M. Lemon,Michael Gale +7 more
TL;DR: It is shown that structured hepatitis C virus (HCV) genomic RNA activates interferon regulatory factor 3 (IRF3), thereby inducing Interferon in cultured cells, and RIG-I is a pathogen receptor that regulates cellular permissiveness to HCV replication and may play a key role inInterferon-based therapies for the treatment of HCV infection.
Journal ArticleDOI
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
Takeshi Saito,Reiko Hirai,Yueh Ming Loo,David M. Owen,Cynthia L. Johnson,Sangita C. Sinha,Shizuo Akira,Takashi Fujita,Michael Gale +8 more
TL;DR: RIG-I is a cytoplasmic sensor of HCV and is governed by RD interactions that are shared with LGP2 as an on/off switch controlling innate defenses, which may have therapeutic implications for immune regulation.