S
Samer Melhem
Researcher at National Institutes of Health
Publications - 1
Citations - 1596
Samer Melhem is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene expression & Catechol-O-methyl transferase. The author has an hindex of 1, co-authored 1 publications receiving 1504 citations.
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Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain
Jingshan Chen,Barbara K. Lipska,Nader D. Halim,Quang D. Ma,Mitsuyuki Matsumoto,Samer Melhem,Bhaskar Kolachana,Thomas M. Hyde,Mary M. Herman,Jose A. Apud,Michael F. Egan,Joel E. Kleinman,Daniel R. Weinberger +12 more
TL;DR: Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function.