Jose A. Apud

TL;DR: Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function.

TL;DR: It is shown that impaired accuracy of working memory could be related to suboptimal cost efficiency of brain functional networks operating in the classical β frequency band, 15–30 Hz, and with biophysical models highlighting the importance of β-band oscillations for long-distance functional connections in brain networks and with pathophysiological models of schizophrenia as a dysconnection syndrome.

TL;DR: In this paper, the effects of tolcapone, a CNS penetrant specific COMT inhibitor, were explored in a randomized, double blind, placebo controlled, and crossover design of this drug in normal subjects stratified by COMT (val158met) genotype.

TL;DR: Thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC, and the correlation with BOLD activation was accentuated in patients as compared with controls in the ventral LPFC.

TL;DR: The results of this study support other data suggesting that the COMT val(108/158)met polymorphism might be an important factor in the cognitive response to antipsychotic medication.