M
Mary M. Herman
Researcher at National Institutes of Health
Publications - 202
Citations - 14339
Mary M. Herman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Neuroepithelial cell & Prefrontal cortex. The author has an hindex of 64, co-authored 202 publications receiving 13714 citations. Previous affiliations of Mary M. Herman include Ames Research Center & St. Elizabeths Hospital.
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Journal ArticleDOI
Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain
Jingshan Chen,Barbara K. Lipska,Nader D. Halim,Quang D. Ma,Mitsuyuki Matsumoto,Samer Melhem,Bhaskar Kolachana,Thomas M. Hyde,Mary M. Herman,Jose A. Apud,Michael F. Egan,Joel E. Kleinman,Daniel R. Weinberger +12 more
TL;DR: Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function.
Journal ArticleDOI
Temporal dynamics and genetic control of transcription in the human prefrontal cortex
Carlo Colantuoni,Barbara K. Lipska,Tianzhang Ye,Thomas M. Hyde,Thomas M. Hyde,Ran Tao,Jeffrey T. Leek,Elizabeth Colantuoni,Abdel G. Elkahloun,Mary M. Herman,Daniel R. Weinberger,Daniel R. Weinberger,Joel E. Kleinman +12 more
TL;DR: The temporal dynamics and genetic control of transcription in human prefrontal cortex in an extensive series of post-mortem brains from fetal development through ageing is explored, finding a wave of gene expression changes occurring during fetal development which are reversed in early postnatal life.
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Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia
Cynthia Shannon Weickert,Thomas M. Hyde,Barbara K. Lipska,Mary M. Herman,D.R. Weinberger,Joel E. Kleinman +5 more
TL;DR: This study demonstrates a reduction in BDNF production and availability in the DLPFC of schizophrenics, and suggests that intrinsic cortical neurons, afferent neurons, and target neurons may receive less trophic support in this disorder.
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Disseminated necrotizing leukoencephalopathy: A complication of treated central nervous system leukemia and lymphoma
TL;DR: This report describes a form of disseminated necrotizing leukoencephalopathy that has been observed in four children with acute lymphoblastic leukemia, and one child with Burkitt's lymphoma terminating in a leukemic phase, which developed either at or shortly after the completion of combined triple intrathecal therapy.
Journal ArticleDOI
Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function.
Mitsuyuki Matsumoto,C. Shannon Weickert,Mayada Akil,Barbara K. Lipska,Thomas M. Hyde,Mary M. Herman,Joel E. Kleinman,Daniel R. Weinberger +7 more
TL;DR: Contrary to expectations that COMT would be expressed predominantly in non-neuronal cells, the present study shows that neurons are the main cell populations expressing COMT mRNA in the prefrontal cortex and striatum.