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Samuel K. Ludwin
Researcher at Montreal Neurological Institute and Hospital
Publications - 69
Citations - 26812
Samuel K. Ludwin is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Remyelination & Myelin. The author has an hindex of 34, co-authored 67 publications receiving 23050 citations. Previous affiliations of Samuel K. Ludwin include McGill University & Queen's University.
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High Frequency of Human Herpesvirus 6 DNA in Multiple Sclerosis Plaques Isolated by Laser Microdissection
Claudio Cermelli,Rossana Berti,Samantha S. Soldan,Michael Mayne,James M. Dambrosia,Samuel K. Ludwin,Steven Jacobson +6 more
TL;DR: Although the frequency of HHV-6 DNA did not differ significantly by sample type,HHV- 6 DNA was significantly more common in MS plaques, suggesting that HHV -6 may play a role in MS pathogenesis.
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Statin Therapy Inhibits Remyelination in the Central Nervous System
Veronique E. Miron,Simone P. Zehntner,Tanja Kuhlmann,Samuel K. Ludwin,Trevor Owens,Timothy E. Kennedy,Barry J. Bedell,Jack P. Antel +7 more
TL;DR: The findings suggest that simvastatin inhibits central nervous system remyelination by blocking progenitor differentiation, indicating the need to monitor effects of systemic immunotherapies that can access the central nervous System on brain tissue-repair processes.
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A syndrome of acute severe muscle necrosis in intensive care unit patients.
TL;DR: Four septic patients and one asthmatic patient are described who developed a severe paralytic disorder in an intensive care unit (ICU), associated with a rise in serum creatine kinase and a severe necrotizing myopathy, providing one of the differential diagnoses for ICU-acquired weakness.
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Evidence for a “dying‐back” gliopathy in demyelinating disease
TL;DR: The results show for the first time that in demyelinating disease, a “dying‐back” process similar to that described in axonal disease can affect the oligodendrocyte.
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