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Samuel K. Ludwin

Researcher at Montreal Neurological Institute and Hospital

Publications -  69
Citations -  26812

Samuel K. Ludwin is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Remyelination & Myelin. The author has an hindex of 34, co-authored 67 publications receiving 23050 citations. Previous affiliations of Samuel K. Ludwin include McGill University & Queen's University.

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Dilemmas in medical ethics in the age of big data

Samuel K. Ludwin, +1 more
- 26 Jul 2017 - 
TL;DR: As rapid discoveries are already bringing further unforeseen challenges, the original Baltimore/Asilomar rules on genetic manipulation were prompted by molecular genetic discoveries and have been more recently reinforced to meet the challenges posed by the new CRISPR technology.
Journal Article

Implicating MicroRNAs as Regulators of Microglia and Astrocyte Responses in Human CNS Inflammatory Disease (P5.018)

Craig S. Moore, +6 more
- 08 Apr 2014 - 
TL;DR: The results demonstrate that unique miRNAs, implicated in situ within astrocytes and microglia/macrophages of MS lesions, can impact glial responses that may be relevant in mechanisms of injury and repair.
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Multiple Sclerosis as a Syndrome-Implications for Future Management

Chris Dwyer, +10 more
- 28 Aug 2020 - 
TL;DR: It is proposed that multiple sclerosis is best characterized as a syndrome rather than a single disease because different pathogenetic mechanisms can result in the constellation of symptoms and signs by which MS is clinically characterized.
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Limited repertoire of HLA-DRB1*0401-restricted MBP111-129-specific T cells in HLA-DRB1*0401 Tg mice and their pathogenic potential.

Jaebong Huh, +7 more
- 01 Jun 2004 - 
TL;DR: The pathogenic potential of HLA-DRB1*0401-restricted MBP111-129-specific T cells in humans is suggested and mild EAE and inflammatory lesions were observed in the spinal cord and the brainstem.
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Identification of P2Y12 as a mediator of migration and inflammation in human microglia

Craig S. Moore, +9 more
- 15 Oct 2014 - 
TL;DR: The role of SIRT1 in interleukin (IL)-10 regulation of human peripheral blood monocytes is investigated and it is suggested that the induction of IL-10 by IFN beta is modulated by SIRT2, which is an attractive therapeutic target in MS.