S
Samuel Navarro
Researcher at University of Valencia
Publications - 204
Citations - 5393
Samuel Navarro is an academic researcher from University of Valencia. The author has contributed to research in topics: Sarcoma & Neuroblastoma. The author has an hindex of 35, co-authored 196 publications receiving 4778 citations. Previous affiliations of Samuel Navarro include Carlos III Health Institute.
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Journal ArticleDOI
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Linda Holmquist-Mengelbier,Erik Fredlund,Tobias Löfstedt,Rosa Noguera,Samuel Navarro,Helén Nilsson,Alexander Pietras,Johan Vallon-Christersson,Åke Borg,Katarina Gradin,Lorenz Poellinger,Sven Påhlman +11 more
TL;DR: High HIF-2alpha protein levels were correlated with advanced clinical stage and high VEGF expression and predicted poor prognosis in a clinical neuroblastoma material and have general tumor biological implications.
Journal ArticleDOI
Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support.
Antonio Llombart-Bosch,Isidro Machado,Samuel Navarro,Franco Bertoni,Patrizia Bacchini,Marco Alberghini,Apollon Karzeladze,Nikita Savelov,S V Petrov,Isabel Alvarado-Cabrero,Doina Mihaila,Philippe Terrier,Jose Antonio López-Guerrero,Piero Picci +13 more
TL;DR: The diagnosis of atypical ES is a challenge for the pathologist and needs support from molecular techniques to perform an optimal differential diagnosis with other small round cell tumors.
Journal ArticleDOI
HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
Alexander Pietras,Loen M. Hansford,A. Sofie Sofie Johnsson,Esther Bridges,Jonas Sjölund,David Gisselsson,Matilda Rehn,Siv Beckman,Rosa Noguera,Samuel Navarro,Jörg Cammenga,Erik Fredlund,David L. Kaplan,Sven Påhlman +13 more
TL;DR: This work identifies HIF-2α as a marker of normoxic neural crest-like neuroblastoma tumor-initiating/stem cells (TICs) isolated from patient bone marrows and Knockdown of Hif-2 α reduced VEGF expression and induced partial sympathetic neuronal differentiation when these TICs were grown in vitro under stem cell-promoting conditions.
Journal ArticleDOI
Quality Assessment of Genetic Markers Used for Therapy Stratification
Inge M. Ambros,Jean Bénard,M. Boavida,Nick Bown,H.N. Caron,Valérie Combaret,Jérôme Couturier,Catarina Darnfors,Olivier Delattre,J. Freeman-Edward,Claudio Gambini,Nicole Gross,Claudia Maria Hattinger,A. Luegmayr,John Lunec,Tommy Martinsson,Katia Mazzocco,Samuel Navarro,Rosa Noguera,Seamus O'Neill,Ulrike Pötschger,S. Rumpler,Franki Speleman,Gian Paolo Tonini,A. Valent,N. Van Roy,Gabriele Amann,B. De Bernardi,Per Kogner,Ruth Ladenstein,Jean Michon,Adj Pearson,Peter F. Ambros +32 more
TL;DR: This study demonstrated the importance of revealing the difficulties and limitations for each technique and problems in interpreting results, which are crucial for therapeutic decisions and led to the formulation of guidelines that are applicable to all kinds of tumors and that contain the standardization of techniques.
Journal ArticleDOI
High Oct4 expression: implications in the pathogenesis of neuroblastic tumours
Ezequiel Monferrer,Rebeca Burgos-Panadero,Maite Blanquer-Maceiras,Adela Cañete,Samuel Navarro,Rosa Noguera +5 more
TL;DR: The results suggest that the Oct4 gene may regulate NBT pathogenic differentiation pathways, and should thus be considered as a target for knockdown when developing novel therapies for high-risk NBT patients.