J
John Lunec
Researcher at Newcastle University
Publications - 148
Citations - 6241
John Lunec is an academic researcher from Newcastle University. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 43, co-authored 141 publications receiving 5797 citations. Previous affiliations of John Lunec include National Chemical Laboratory & University of Leicester.
Papers
More filters
Journal ArticleDOI
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism
Godefridus J. Peters,H. H. J. Backus,Sarah J. Freemantle,B. Van Triest,Giovanni Codacci-Pisanelli,C.L. van der Wilt,Kees Smid,John Lunec,Calvert Ah,Sharon Marsh,Howard L. McLeod,Elisabeth Bloemena,Sybren L. Meijer,Gerrit Jansen,C.J. van Groeningen,H.M. Pinedo +15 more
TL;DR: In patients, TS levels as determined by enzyme activity assays, immunohistochemistry and mRNA expression, were related to a response to 5FU, and the clear retrospective relation between TS levels and response now forms the basis for a prospective study.
Journal Article
Prognostic Significance of HER2 and HER4 Coexpression in Childhood Medulloblastoma
TL;DR: The hypothesis that HER2-HER4 receptor heterodimerization is of particular biological significance in this disease is suggested and the first to demonstrate potential clinical significance of EGFR family heterodimers in human cancer is demonstrated.
Journal ArticleDOI
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
TL;DR: Five alternatively spliced mdm2 gene transcripts in a range of human cancers and their absence in normal tissues suggest a reassessment of the transforming mechanisms of mDM2 and its relation to p53.
Journal ArticleDOI
Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay
Katleen De Preter,Frank Speleman,Valérie Combaret,John Lunec,Genevieve Laureys,Bert H.J. Eussen,Nadine Francotte,Julian Board,Andrew D.J. Pearson,Anne De Paepe,Nadine Van Roy,Jo Vandesompele +11 more
TL;DR: A real-time quantitative PCR assay is developed and evaluated as an alternative for time-consuming Southern blot analysis (SB), and as a second independent technique in parallel with fluorescence in situ hybridization (FISH) analysis, which pointed out that DDX1 and NAG amplification has no additional adverse effect on prognosis.
Journal Article
Evidence for the Development of p53 Mutations after Cytotoxic Therapy in a Neuroblastoma Cell Line
TL;DR: If p53 mutations develop frequently in relapsed neuroblastoma, cytotoxic agents more sensitive to mutant p53 might be more effective at relapse.