Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Linda Holmquist-Mengelbier,Erik Fredlund,Tobias Löfstedt,Rosa Noguera,Samuel Navarro,Helén Nilsson,Alexander Pietras,Johan Vallon-Christersson,Åke Borg,Katarina Gradin,Lorenz Poellinger,Sven Påhlman +11 more
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TLDR
High HIF-2alpha protein levels were correlated with advanced clinical stage and high VEGF expression and predicted poor prognosis in a clinical neuroblastoma material and have general tumor biological implications.About:
This article is published in Cancer Cell.The article was published on 2006-11-01 and is currently open access. It has received 681 citations till now. The article focuses on the topics: Neuroblastoma & Gene knockdown.read more
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Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
TL;DR: HIF plays a central role in the transcriptional response to changes in oxygen availability and is modulated by FIH1-mediated asparagine hydroxylation, and HIF-modulatory drugs are now being developed for diverse diseases.
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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
TL;DR: A more thorough understanding of the unique roles performed by HIF1α and HIF2α in human neoplasia is warranted.
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The impact of O2 availability on human cancer.
TL;DR: Over the past decade work from many laboratories has elucidated the mechanisms by which hypoxia-inducible factors (HIFs) modulate tumour cell metabolism, angiogenesis, growth and metastasis.
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Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
Zhizhong Li,Shideng Bao,Shideng Bao,Qiulian Wu,Qiulian Wu,Hui Wang,Christine E. Eyler,Sith Sathornsumetee,Qing Shi,Yiting Cao,Justin D. Lathia,Justin D. Lathia,Roger E. McLendon,Anita B. Hjelmeland,Anita B. Hjelmeland,Jeremy N. Rich +15 more
TL;DR: It is demonstrated that hypoxia-inducible factor HIF2alpha and multiple HIF-regulated genes are preferentially expressed in GSCs in comparison to non-stem tumor cells and normal neural progenitors.
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HIF Transcription Factors, Inflammation, and Immunity
Asis Palazon,Ananda W. Goldrath,Victor Nizet,Victor Nizet,Randall S. Johnson,Randall S. Johnson +5 more
TL;DR: How oxygen sensing in the immune microenvironment shapes immunological response is discussed and how HIF and the hypoxia pathway control innate and adaptive immunity is examined.
References
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Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
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Hypoxia — a key regulatory factor in tumour growth
TL;DR: Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death, and many elements of the hypoxia-response pathway are good candidates for therapeutic targeting.
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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Andrew C. R Epstein,Jonathan M. Gleadle,Luke A. McNeill,Kirsty S. Hewitson,J F O'Rourke,David R. Mole,Mridul Mukherji,Eric Metzen,Michael A Wilson,Anu Dhanda,Ya-Min Tian,Norma Masson,Donald L. Hamilton,Panu Jaakkola,Robert Barstead,Jonathan Hodgkin,Patrick H. Maxwell,Christopher W. Pugh,Christopher J. Schofield,Peter J. Ratcliffe +19 more
TL;DR: Direct modulation of recombinant enzyme activity by graded hypoxia, iron chelation, and cobaltous ions mirrors the characteristics of HIF induction in vivo, fulfilling requirements for these enzymes being oxygen sensors that regulate HIF.
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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.
Michael Höckel,Peter Vaupel +1 more
TL;DR: Because malignant tumors no longer execute functions necessary for homeostasis (such as the production of adequate amounts of adenosine triphosphate), the physiology-based definitions of the term "hypoxia" are not necessarily valid for malignant tumor patients.
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Exploiting tumour hypoxia in cancer treatment.
TL;DR: Solid tumours contain regions at very low oxygen concentrations (hypoxia), often surrounding areas of necrosis, which provides an opportunity for tumour-selective therapy, including prodrugs activated by Hypoxia, hypoxia-specific gene therapy, targeting the hypoxIA-inducible factor 1 transcription factor, and recombinant anaerobic bacteria.