J
Jérôme Couturier
Researcher at Curie Institute
Publications - 163
Citations - 9552
Jérôme Couturier is an academic researcher from Curie Institute. The author has contributed to research in topics: Comparative genomic hybridization & Cancer. The author has an hindex of 56, co-authored 163 publications receiving 8862 citations. Previous affiliations of Jérôme Couturier include University of Leicester & PSL Research University.
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Journal ArticleDOI
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
Corine Bertolotto,Fabienne Lesueur,Sandy Giuliano,Thomas Strub,Mahaut de Lichy,Karine Bille,Philippe Dessen,Benoit d’Hayer,Hamida Mohamdi,Audrey Remenieras,Eve Maubec,Arnaud de la Fouchardière,Vincent Molinié,Pierre Vabres,Stéphane Dalle,N. Poulalhon,Tanguy Martin-Denavit,Luc Thomas,Pascale Andry-Benzaquen,Nicolas Dupin,F. Boitier,Annick Rossi,Jean-Luc Perrot,Bruno Labeille,Caroline Robert,Bernard Escudier,Olivier Caron,Laurence Brugières,Simon Saule,Betty Gardie,Sophie Gad,Stéphane Richard,Jérôme Couturier,Bin Tean Teh,Paola Ghiorzo,Lorenza Pastorino,Susana Puig,Celia Badenas,Håkan Olsson,Christian Ingvar,Etienne Rouleau,Rosette Lidereau,Philippe Bahadoran,Philippe Vielh,Eve Corda,Hélène Blanché,Diana Zelenika,Pilar Galan,François Aubin,Bertrand Bachollet,Celine Becuwe,Pascaline Berthet,Yves-Jean Bignon,Valérie Bonadona,Jean -Louis Bonafe,Marie -Noelle Bonnet-Dupeyron,Frédéric Cambazard,Jacqueline Chevrant-Breton,Isabelle Coupier,Sophie Dalac,Liliane Demange,Michel D'Incan,Catherine Dugast,Laurence Faivre,Lynda Vincent-Fetita,Marion Gauthier-Villars,Brigitte Gilbert,Florent Grange,Jean-Jacques Grob,Philippe Humbert,Nicolas Janin,Pascal Joly,Delphine Kerob,Christine Lasset,Dominique Leroux,Julien Levang,Jean -Marc Limacher,Cristina Bulai Livideanu,Michel Longy,Alain Lortholary,Dominique Stoppa-Lyonnet,Sandrine Mansard,Ludovic Mansuy,Karine Marrou,Christine Mateus,Christine Maugard,Nicolas Meyer,Catherine Noguès,Pierre Souteyrand,Laurence Venat-Bouvet,Hélène Zattara,Valérie Chaudru,Gilbert M. Lenoir,Mark Lathrop,Irwin Davidson,Marie-Françoise Avril,Florence Demenais,Robert Ballotti,Brigitte Bressac-de Paillerets +98 more
TL;DR: A germline missense substitution in MITF (Mi-E318K) is identified that occurred at a significantly higher frequency in genetically enriched patients affected with melanoma, RCC or both cancers, when compared with controls and provides insights into the link between SUMOylation, transcription and cancer.
Journal ArticleDOI
A new member of the ETS family fused to EWS in Ewing tumors
Martine Peter,Jérôme Couturier,Hélène Pacquement,Jean Michon,Gilles Thomas,Henri Magdelenat,Olivier Delattre +6 more
TL;DR: A new member of the ETS family is identified, called FEV, which is fused to EWS in a subset of Ewing tumors, and expression was only detected in adult prostate and small intestine but not in other adult nor in fetal tissues, thus indicating that FEV has a restricted expression pattern.
Journal Article
Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice.
Eric Tartour,François Fossiez,Isabelle Joyeux,Annie Galinha,Alain Gey,Emmanuel Claret,Xavier Sastre-Garau,Jérôme Couturier,Véronique Mosseri,Virginie Vives,Jacques Banchereau,Wolf H. Fridman,John Wijdenes,Serge Lebecque,Catherine Sautèes-Fridman +14 more
TL;DR: It was shown that in vitro, IL-17 increases IL-6 and IL-8 secretion by cervical carcinoma cell lines at both protein and mRNA levels, and behaves like a T-cell-specific cytokine with paradoxical tumor-promoting activity.
Journal ArticleDOI
PRCC-TFE3 renal carcinomas: morphologic, immunohistochemical, ultrastructural, and molecular analysis of an entity associated with the t(X;1)(p11.2;q21).
Pedram Argani,Cristina R. Antonescu,Jérôme Couturier,Jean-Christophe Fournet,Raphael Sciot,Maria Debiec-Rychter,Brian Hutchinson,Victor E. Reuter,Lilliane Boccon-Gibod,Charles F. Timmons,Naiel Hafez,Marc Ladanyi +11 more
TL;DR: The reappraisal of genetically defined subsets of renal tumors can help to highlight the key pathologic features of specific neoplastic entities and there is experimental evidence suggesting that these tumors may show differential sensitivity to certain chemotherapeutic agents.
Journal ArticleDOI
Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma
Isabelle Janoueix-Lerosey,Gudrun Schleiermacher,Evi Michels,Véronique Mosseri,Agnès Ribeiro,Delphine Lequin,Joëlle Vermeulen,Jérôme Couturier,Michel Peuchmaur,Alexander Valent,Dominique Plantaz,Hervé Rubie,Dominique Valteau-Couanet,Caroline Thomas,Valérie Combaret,Raphael Rousseau,Angelika Eggert,Jean Michon,Frank Speleman,Olivier Delattre +19 more
TL;DR: The analysis of the overall genomic pattern, which probably unravels particular genomic instability mechanisms rather than the analysis of individual markers, is essential to predict relapse in NB patients.