S
Sandip Chatterjee
Researcher at Scripps Research Institute
Publications - 9
Citations - 794
Sandip Chatterjee is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Metaproteomics & Proteases. The author has an hindex of 7, co-authored 9 publications receiving 559 citations. Previous affiliations of Sandip Chatterjee include Princeton University & University of California, San Francisco.
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Journal ArticleDOI
Proteome-wide covalent ligand discovery in native biological systems
Keriann M. Backus,Bruno E. Correia,Kenneth M. Lum,Stefano Forli,Benjamin D. Horning,Gonzalo E. González-Páez,Sandip Chatterjee,Bryan R. Lanning,John R. Teijaro,Arthur J. Olson,Dennis W. Wolan,Benjamin F. Cravatt +11 more
TL;DR: A quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins in human proteomes and cells provides a greatly expanded portrait of the ligandable proteome and furnishes compounds that can illuminate protein functions in native biological systems.
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Knockdown of Parhyale Ultrabithorax recapitulates evolutionary changes in crustacean appendage morphology
Danielle M. Liubicich,Julia Serano,Anastasios Pavlopoulos,Zacharias Kontarakis,Meredith E. Protas,Elaine Kwan,Sandip Chatterjee,Khoa D. Tran,Michalis Averof,Nipam H. Patel +9 more
TL;DR: Critical evidence is provided supporting the proposition that changes in Ubx expression have played a role in generating crustacean appendage diversity and general insights into the mechanisms of morphological evolution are lent.
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A comprehensive and scalable database search system for metaproteomics
Sandip Chatterjee,Gregory S. Stupp,Sung Kyu Park,Jean-Christophe Ducom,John R. Yates,Andrew I. Su,Dennis W. Wolan +6 more
TL;DR: A broadly applicable metaproteomic analysis method (ComPIL) that addresses protein database size limitations and allows proteomic searches to be performed with database sizes much larger than previously possible is designed.
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Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides.
Yaping Sun,Zhiqiang Dong,Hadie Khodabakhsh,Hadie Khodabakhsh,Sandip Chatterjee,Sandip Chatterjee,Su Guo +6 more
TL;DR: The results reveal a previously unknown effect of cardiac glycosides on DA neuronal survival and suggest that it is mediated through ATP1A3 inhibition, oxidative stress, and p53 and elucidate potential approaches for counteracting the neurotoxicity of this valuable class of medications.
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Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria
Emily J. Roncase,Clara Moon,Sandip Chatterjee,Gonzalo E. González-Páez,Charles S. Craik,Anthony J. O’Donoghue,Dennis W. Wolan +6 more
TL;DR: The combination of chemical biological, biophysical, and biochemical techniques presented here to elucidate and characterize PmC11 substrate selectivity can be expanded to other proteases and the development of chemical tools to study these essential proteins in biologically relevant samples, such as the highly complex distal gut microbiome.