D
Dennis W. Wolan
Researcher at Scripps Research Institute
Publications - 88
Citations - 3792
Dennis W. Wolan is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Proteases & Metaproteomics. The author has an hindex of 25, co-authored 84 publications receiving 2716 citations. Previous affiliations of Dennis W. Wolan include Torrey Pines Institute for Molecular Studies & Cleveland Clinic Lerner Research Institute.
Papers
More filters
Journal ArticleDOI
METLIN: A Technology Platform for Identifying Knowns and Unknowns
Carlos Guijas,J. Rafael Montenegro-Burke,Xavier Domingo-Almenara,Amelia Palermo,Benedikt Warth,Gerrit Hermann,Gunda Koellensperger,Tao Huan,Winnie Uritboonthai,Aries E. Aisporna,Dennis W. Wolan,Mary E. Spilker,H. Paul Benton,Gary Siuzdak +13 more
TL;DR: METLIN now features in silico MS/MS data, which has been made possible through the creation of algorithms trained on METLIN's MS/ MS data from both standards and their isotope analogues, being designed to address the characterization of known and unknown molecules.
Journal ArticleDOI
Proteome-wide covalent ligand discovery in native biological systems
Keriann M. Backus,Bruno E. Correia,Kenneth M. Lum,Stefano Forli,Benjamin D. Horning,Gonzalo E. González-Páez,Sandip Chatterjee,Bryan R. Lanning,John R. Teijaro,Arthur J. Olson,Dennis W. Wolan,Benjamin F. Cravatt +11 more
TL;DR: A quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins in human proteomes and cells provides a greatly expanded portrait of the ligandable proteome and furnishes compounds that can illuminate protein functions in native biological systems.
Journal ArticleDOI
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
Emily N. Chin,Chenguang Yu,Chenguang Yu,Vincent F. Vartabedian,Ying Jia,Manoj Kumar,Ana M. Gamo,William Vernier,Sabrina H. Ali,Mildred Kissai,Daniel C. Lazar,Nhan T. Nguyen,Laura E. Pereira,Brent Benish,Ashley K. Woods,Sean B. Joseph,Alan Chu,Kristen Johnson,Philipp N. Sander,Francisco Martínez-Peña,Eric Hampton,Travis S. Young,Dennis W. Wolan,Arnab K. Chatterjee,Peter G. Schultz,Peter G. Schultz,H. Michael Petrassi,John R. Teijaro,Luke L. Lairson +28 more
TL;DR: A non-nucleotide, small-molecule STING agonist, termed SR-717, that demonstrates broad interspecies and interallelic specificity and functions as a direct cyclic guanosine monophosphate–adenosine monophile mimetic that induces the same “closed” conformation of STING.
Journal ArticleDOI
Domain Swapping in Inducible Nitric-oxide Synthase ELECTRON TRANSFER OCCURS BETWEEN FLAVIN AND HEME GROUPS LOCATED ON ADJACENT SUBUNITS IN THE DIMER
TL;DR: Resonance Raman characterization of the heme-l-Arg interaction confirmed that E371A only prevents l-Arg binding in the mutated oxygenase domain, which implies that domain swapping occurs in an iNOS dimer to properly align reductase and oxygenase domains for NO synthesis.
Journal ArticleDOI
Small-Molecule Activators of a Proenzyme
TL;DR: The identification and characterization of the first small molecules that directly activate proenzymes will enable direct control of the executioner caspases in apoptosis and in cellular differentiation and presage the discovery of other proen enzyme activators to explore fundamental processes of proenzyme activation and their fate-determining roles in biology.