S
SangJoon Lee
Researcher at St. Jude Children's Research Hospital
Publications - 6
Citations - 476
SangJoon Lee is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Innate immune system & Pyroptosis. The author has an hindex of 3, co-authored 6 publications receiving 88 citations.
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Journal ArticleDOI
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines.
TL;DR: This review focuses on the present understanding of innate immune responses, inflammasome activation, inflammatory cell death pathways, and cytokine secretion during SARS-CoV, MERS- CoV, and SARS -CoV-2 infection.
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AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
SangJoon Lee,Rajendra Karki,Yaqiu Wang,Lam Nhat Nguyen,Ravi C. Kalathur,Thirumala-Devi Kanneganti +5 more
TL;DR: AIM2 regulates the innate immune sensors pyrin and ZBP1 to drive inflammatory signalling and a form of inflammatory cell death known as PANoptosis, and provide host protection during infections with herpes simplex virus 1 and Francisella novicida as discussed by the authors.
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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Rajendra Karki,Balamurugan Sundaram,Bhesh Raj Sharma,SangJoon Lee,R. K. Subbarao Malireddi,Lam Nhat Nguyen,Shelbi Christgen,Min Zheng,Yaqiu Wang,Parimal Samir,Geoffrey Neale,Peter Vogel,Thirumala-Devi Kanneganti +12 more
TL;DR: In this article, the authors identify and characterize ADAR1's interaction with Z-DNA binding protein 1 (ZBP1), defining its role in cell death regulation and tumorigenesis.
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PANoptosis in microbial infection.
TL;DR: It is proposed that re-examining the role of cell death and inflammatory cytokines through the lens of PANoptosis will advance the understanding of host–pathogen evolution and may reveal new treatment strategies for controlling a wide range of infectious diseases.
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Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
R. K. Subbarao Malireddi,Rajendra Karki,Balamurugan Sundaram,Balabhaskararao Kancharana,SangJoon Lee,Parimal Samir,Thirumala-Devi Kanneganti +6 more
TL;DR: In this article, the authors analyzed expression of several cytokines that are modulated in tumors and found correlations between cytokine expression and mortality, and showed that PANoptosis, induced by synergism of TNF-α and IFN-γ, is an important mechanism to kill cancer cells and suppress tumor growth that could be therapeutically targeted.