Sanjeev V. Kothare

TL;DR: This study evaluates the association of the TSC1 and TSC2 genotype with patient and disease characteristics in a retrospective review of a large TSC Natural History Database consisting of 919 patients with TSC.

TL;DR: This work analyzed an extensive real‐world dataset containing over 20,000 nightly sleep observations matched to subsequent challenging daytime behaviors across 67 individuals with low‐functioning autism living in two U.S. residential facilities, finding a statistically significant predictive relationship between sleep patterns and problematic daytime behavior.

TL;DR: The combination of chronobiology and epilepsy offers novel diagnostic and therapeutic management options and temporal fluctuations of seizure susceptibility based on sleep homeostasis and circadian phase in selected epilepsies may provide predictability based on mathematical models.

TL;DR: Improving sleep has been noted to improve seizure frequency and an overall well-being in patients with epilepsy, and an emphasis should be given to address sleep in patientsWith epilepsy, poor sleep is associated with worsened quality of life, psychological function, and memory.

TL;DR: Recommendations for minimum care standards for people with IDD-E include therapy to control seizures should be individualized, with drug selection based on seizure types, epilepsy syndrome, concomitant medications, and comorbid disorders.